DegronMD

Uniprot ID: Q69YH5

Source protein: Cell division cycle-associated protein 2

Source gene: CDCA2

Class: DEG_APCC_DBOX_1

Location: 509:517

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9163

ASA_SCORE: 103.3111

COIL: 0.742

CONS_SCORE: 0.371

DSS_SCORE: 0.3449

HELIX: 0.1926

FCONS_SCORE: 0.8331

RIG_SCORE: 0.775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R510I	TCGA-E6-A1LX	UCEC	TCGA	RRNQLVSVV	DEG_APCC_DBOX_1	0.8102
p.R510I	DO41020	UCEC	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.8102
p.R509I	TCGA-RS-A6TO	HNSC	TCGA	RRNQLVSVV	DEG_APCC_DBOX_1	0.6991
p.R509I	DO219060	HNSC	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.6991
p.V514L	DO224801	COCA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.5654
p.G501C	DO229028	LICA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.1111
p.V521F	DO229037	LICA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.2222
p.V500F	DO34696	PACA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.0833
p.C522F	DO229232	THCA	ICGC	RRNQLVSVV	DEG_APCC_DBOX_1	0.1944
p.L525W	SIDM00791	Chronic Myelogenous Leukemia	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	0.1111
p.L525W	SIDM00836	Colorectal Carcinoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	0.1111
p.L525W	SIDM00839	Colorectal Carcinoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	0.1111
p.L513F	SIDM01076	B-Lymphoblastic Leukemia	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	0.6981
p.L513F	SIDM00208	Glioblastoma	GDSC	RRNQLVSVV	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YH5	Cell division cycle-associated protein 2	DEG_APCC_DBOX_1	509:517	RRNQLVSVV	APC,CDC20,FZR1	0.9163	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons