DegronMD

Uniprot ID: Q14654

Source protein: ATP-sensitive inward rectifier potassium channel 11

Source gene: KCNJ11

Class: DEG_MDM2_SWIB_1

Location: 86:93

E3 ligase: MDM2

DEGRON score: 0.6439

ASA_SCORE: 53.525

COIL: 0.0458

CONS_SCORE: 0.3539

DSS_SCORE: 0.0005

HELIX: 0.9459

FCONS_SCORE: 1.2286

RIG_SCORE: 1.0768

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R89H	HCT-15	large_intestine	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	0.8244
p.A89V	SIDM00845	Burkitt's Lymphoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	0.5825
p.A89V	ACH-000786	Lymphoma	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	0.5825
p.A94T	TCGA-A5-A0G2	UCEC	TCGA	FAMAWWLI	DEG_MDM2_SWIB_1	0.3056
p.A94T	DO41235	UCEC	ICGC	FAMAWWLI	DEG_MDM2_SWIB_1	0.3056
p.A96T	TCGA-FI-A2D5	UCEC	TCGA	FAMAWWLI	DEG_MDM2_SWIB_1	0.25
p.A96T	DO41331	UCEC	ICGC	FAMAWWLI	DEG_MDM2_SWIB_1	0.25
p.H97Y	ACH-000829	Myeloma	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	0.2222
p.A101D	SIDM00393	Gastric Carcinoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111
p.A101D	ACH-001653	Gastric Cancer	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111
p.A101D	SK-GT-2	stomach	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111
p.S78Y	SIDM00282	Colorectal Carcinoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111
p.S78Y	ACH-000998	Colon/Colorectal Cancer	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111
p.S78Y	CW-2	large_intestine	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	0.1111

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14654	ATP-sensitive inward rectifier potassium channel 11	DEG_MDM2_SWIB_1	86:93	FAMAWWLI	MDM2	0.6439	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons