DegronMD - Q14654(KCNJ11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A94T	TCGA-A5-A0G2	UCEC	TCGA	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.3056
p.A94T	DO41235	UCEC	ICGC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.3056
p.T336N	TCGA-AX-A1CE	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.25
p.T336N	DO42280	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.25
p.R347H	TCGA-B5-A0K9	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.R347H	TCGA-VQ-A8P2	STAD	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.R347H	DO233813	GACA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.R347H	DO51761	STAD	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.R347H	DO42097	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.D352N	TCGA-CN-5369	HNSC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1389
p.D352N	TCGA-FW-A3R5	SKCM	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1389
p.D352N	DO16069	HNSC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1389
p.D352N	DO37406	SKCM	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1389
p.T345M	TCGA-EO-A22R	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation altering degron motif	0.7423
p.T345M	DO42713	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation altering degron motif	0.7423
p.A96T	TCGA-FI-A2D5	UCEC	TCGA	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.25
p.A96T	DO41331	UCEC	ICGC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.25
p.L349R	TCGA-IB-7651	PAAD	TCGA	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2222
p.L349R	DO46657	PAAD	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2222
p.V337I	DO229010	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V337I	DO229016	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V337I	DO229003	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V337I	DO229005	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.D350G	DO228215	LICA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1944
p.A89V	SIDM00845	Burkitt's Lymphoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation altering degron motif	0.5825
p.A89V	ACH-000786	Lymphoma	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation altering degron motif	0.5825
p.A101D	SIDM00393	Gastric Carcinoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.A101D	ACH-001653	Gastric Cancer	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.A101D	SK-GT-2	stomach	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.S78Y	SIDM00282	Colorectal Carcinoma	GDSC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.S78Y	ACH-000998	Colon/Colorectal Cancer	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.S78Y	CW-2	large intestine	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.1111
p.G334A	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1944
p.G334A	ACH-000563	Lung Cancer	CCLE	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1944
p.G334A	EBC-1	lung	COSMIC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.1944
p.S354N	SIDM01619	Endometrial Carcinoma	GDSC	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.0833
p.S354N	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPTPLCT	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.0833
p.H97Y	ACH-000829	Myeloma	CCLE	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation rewiring degron network	0.2222
p.R89H	HCT-15	large intestine	COSMIC	FAMAWWLI	DEG_MDM2_SWIB_1	86:93	Mutation altering degron motif	0.8244

Kaplan plot for KCNJ11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNJ11

UniProt ID: Q14654

Entrez ID: 3767

Protein name: ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNJ11 in