DegronMD

Uniprot ID: Q14654

Source protein: ATP-sensitive inward rectifier potassium channel 11

Source gene: KCNJ11

Class: DEG_SCF_FBW7_1

Location: 339:345

E3 ligase: FBXW7

DEGRON score: 0.9128

ASA_SCORE: 53.2571

COIL: 0.8496

CONS_SCORE: 0.5162

DSS_SCORE: 0.3016

HELIX: 0.0101

FCONS_SCORE: 1.0008

RIG_SCORE: 0.8312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T336N	TCGA-AX-A1CE	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.25
p.T336N	DO42280	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.25
p.R347H	TCGA-B5-A0K9	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.R347H	TCGA-VQ-A8P2	STAD	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.R347H	DO233813	GACA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.R347H	DO51761	STAD	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.R347H	DO42097	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.D352N	TCGA-CN-5369	HNSC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.1389
p.D352N	TCGA-FW-A3R5	SKCM	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.1389
p.D352N	DO16069	HNSC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.1389
p.D352N	DO37406	SKCM	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.1389
p.T345M	TCGA-EO-A22R	UCEC	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.7423
p.T345M	DO42713	UCEC	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.7423
p.L349R	TCGA-IB-7651	PAAD	TCGA	VPTPLCT	DEG_SCF_FBW7_1	0.2222
p.L349R	DO46657	PAAD	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2222
p.V337I	DO229010	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.V337I	DO229016	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.V337I	DO229003	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.V337I	DO229005	COCA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.2778
p.D350G	DO228215	LICA	ICGC	VPTPLCT	DEG_SCF_FBW7_1	0.1944
p.G334A	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VPTPLCT	DEG_SCF_FBW7_1	0.1944
p.G334A	ACH-000563	Lung Cancer	CCLE	VPTPLCT	DEG_SCF_FBW7_1	0.1944
p.G334A	EBC-1	lung	COSMIC	VPTPLCT	DEG_SCF_FBW7_1	0.1944
p.S354N	SIDM01619	Endometrial Carcinoma	GDSC	VPTPLCT	DEG_SCF_FBW7_1	0.0833
p.S354N	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPTPLCT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14654	ATP-sensitive inward rectifier potassium channel 11	DEG_SCF_FBW7_1	339:345	VPTPLCT	FBXW7	0.9128	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons