DegronMD

Uniprot ID: P12259

Source protein: Coagulation factor V

Source gene: F5

Class: LIG_APCC_ABBA_1

Location: 215:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6083

ASA_SCORE: 19.35

COIL: 0.2577

CONS_SCORE: 0.8738

DSS_SCORE: 0.0693

HELIX: 0.0198

FCONS_SCORE: 1.4269

RIG_SCORE: 0.9487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D208H	TCGA-A8-A09G	BRCA	TCGA	FAVFDE	LIG_APCC_ABBA_1	0.1389
p.D208H	DO1990	BRCA	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.1389
p.T206M	TCGA-B5-A1MX	UCEC	TCGA	FAVFDE	LIG_APCC_ABBA_1	0.0833
p.T206M	DO41999	UCEC	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.0833
p.D219H	TCGA-DK-A3WW	BLCA	TCGA	FAVFDE	LIG_APCC_ABBA_1	0.6577
p.D219H	DO481	BLCA	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.6577
p.Q226H	TCGA-HZ-A4BK	PAAD	TCGA	FAVFDE	LIG_APCC_ABBA_1	0.1667
p.Q226H	DO32781	PAAD	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.1667
p.S223I	TCGA-Y8-A896	KIRP	TCGA	FAVFDE	LIG_APCC_ABBA_1	0.25
p.S223I	DO49803	KIRP	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.25
p.A216D	DO228976	LICA	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.6682
p.S225R	DO229029	LICA	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.1944
p.S225R	SIDM00394	Cervical Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	0.1944
p.S225R	ACH-001650	Cervical Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	0.1944
p.S225R	SISO	cervix	COSMIC	FAVFDE	LIG_APCC_ABBA_1	0.1944
p.W224R	DO222363	MELA	ICGC	FAVFDE	LIG_APCC_ABBA_1	0.2222
p.S229F	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	0.0833
p.S229F	ACH-000444	Lung Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	0.0833
p.S229F	LU-99A	lung	COSMIC	FAVFDE	LIG_APCC_ABBA_1	0.0833
p.K222M	SIDM01066	Melanoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	0.2778
p.K222M	ACH-000650	Skin Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	0.2778
p.K222M	IGR-37	skin	COSMIC	FAVFDE	LIG_APCC_ABBA_1	0.2778
p.F215V	SIDM01611	Endometrial Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	0.5957
p.F215V	ACH-000996	Endometrial/Uterine Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12259	Coagulation factor V	LIG_APCC_ABBA_1	215:220	FAVFDE	APC,CDC20,FZR1	0.6083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons