DegronMD - P12259(F5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1381K	TCGA-22-4613	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0556
p.Q1381K	DO26468	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0556
p.E1390Q	TCGA-34-2600	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.E1390Q	DO27081	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.S1385C	TCGA-56-8628	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1667
p.S1385C	DO45433	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1667
p.P1392S	TCGA-86-6851	LUAD	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5641
p.P1392S	TCGA-AX-A0J1	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5641
p.P1392S	DO23798	LUAD	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5641
p.P1392S	DO41199	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5641
p.L1388I	TCGA-A5-A2K5	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.25
p.L1388I	DO41379	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.25
p.D208H	TCGA-A8-A09G	BRCA	TCGA	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1389
p.D208H	DO1990	BRCA	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1389
p.D1759G	TCGA-AA-3984	COAD	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation altering degron motif	0.7198
p.D1759G	DO9002	COAD	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation altering degron motif	0.7198
p.L56I	TCGA-AG-3892	READ	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	TCGA-AP-A059	UCEC	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	TCGA-BS-A0UF	UCEC	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	TCGA-EI-6917	READ	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	DO36394	READ	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	DO36881	READ	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	DO41488	UCEC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.L56I	DO41361	UCEC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1667
p.S1389N	TCGA-AN-A0FW	BRCA	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.2778
p.S1389N	DO2825	BRCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.2778
p.D1396E	TCGA-AP-A1DK	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5647
p.D1396E	DO42033	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.5647
p.S1760T	TCGA-AR-A256	BRCA	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.3056
p.S1760T	DO4155	BRCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.3056
p.D1387Y	TCGA-B5-A1MR	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.2222
p.D1387Y	DO41758	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.2222
p.T206M	TCGA-B5-A1MX	UCEC	TCGA	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.0833
p.T206M	DO41999	UCEC	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.0833
p.D219H	TCGA-DK-A3WW	BLCA	TCGA	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation altering degron motif	0.6577
p.D219H	DO481	BLCA	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation altering degron motif	0.6577
p.G1746D	TCGA-DU-6407	LGG	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1389
p.G1746D	DO22295	LGG	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1389
p.S1385F	TCGA-EE-A2MC	SKCM	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1667
p.S1385F	DO37559	SKCM	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1667
p.M1764R	TCGA-EO-A22U	UCEC	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764R	DO43755	UCEC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.Q226H	TCGA-HZ-A4BK	PAAD	TCGA	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1667
p.Q226H	DO32781	PAAD	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1667
p.P1401S	TCGA-WE-A8K4	SKCM	TCGA	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1944
p.P1401S	DO51281	SKCM	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1944
p.S223I	TCGA-Y8-A896	KIRP	TCGA	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.25
p.S223I	DO49803	KIRP	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.25
p.M1764V	DO230334	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO227999	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO229010	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO229013	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO229016	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO229005	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO234285	ESAD	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO229505	LAML	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO230993	LUSC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.M1764V	DO230990	LUSC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1944
p.L1397F	DO229010	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.L1397F	DO229013	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.L1397F	DO229016	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.L1397F	DO229003	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.L1397F	DO229505	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.3056
p.P1404S	DO229013	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.P1404S	DO229016	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.P1404S	DO229005	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.P1404S	DO230659	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.P1404S	DO231140	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.P1404S	DO230550	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.1111
p.D1396H	DO233726	GACA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation altering degron motif	0.7688
p.A216D	DO228976	LICA	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation altering degron motif	0.6682
p.S225R	DO229029	LICA	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1944
p.S225R	SIDM00394	Cervical Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1944
p.S225R	ACH-001650	Cervical Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1944
p.S225R	SISO	cervix	COSMIC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.1944
p.P71Q	DO229027	LICA	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.25
p.L54F	DO26469	LUSC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation rewiring degron network	0.1111
p.D1765N	DO220862	MELA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1667
p.T1382I	DO220878	MELA	ICGC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0833
p.T1382I	SIDM01095	Rhabdomyosarcoma	GDSC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0833
p.T1382I	ACH-000833	Sarcoma	CCLE	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0833
p.T1382I	SJRH30	soft tissue	COSMIC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.0833
p.W224R	DO222363	MELA	ICGC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.2222
p.R67I	DO229224	THCA	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	62:68	Mutation altering degron motif	0.6991
p.D1765E	SIDM00987	Thyroid Gland Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1667
p.D1765E	BHT-101	thyroid	COSMIC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1667
p.I1755M	SIDM00798	Rhabdomyosarcoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation altering degron motif	0.6507
p.I1755M	SIDM00839	Colorectal Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation altering degron motif	0.6507
p.L1749V	SIDM00336	Melanoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.2222
p.L1749V	SIDM00945	Colorectal Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.2222
p.L1749V	SIDM01101	Neuroblastoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.2222
p.S229F	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.0833
p.S229F	ACH-000444	Lung Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.0833
p.S229F	LU-99A	lung	COSMIC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.0833
p.K222M	SIDM01066	Melanoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.2778
p.K222M	ACH-000650	Skin Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.2778
p.K222M	IGR-37	skin	COSMIC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation rewiring degron network	0.2778
p.F215V	SIDM01611	Endometrial Carcinoma	GDSC	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation altering degron motif	0.5957
p.F215V	ACH-000996	Endometrial/Uterine Cancer	CCLE	FAVFDE	LIG_APCC_ABBA_1	215:220	Mutation altering degron motif	0.5957
p.G1746S	ACH-001634	Leukemia	CCLE	KGILHKD	LIG_APCC_ABBAyCdc20_2	1753:1759	Mutation rewiring degron network	0.1389
p.T1387I	SJRH30	soft tissue	COSMIC	MPLFAD	LIG_APCC_ABBA_1	1391:1396	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F5

UniProt ID: P12259

Entrez ID: 2153

Protein name: Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for F5 in