DegronMD

Uniprot ID: P12259

Source protein: Coagulation factor V

Source gene: F5

Class: LIG_APCC_ABBAyCdc20_2

Location: 1753:1759

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5437

ASA_SCORE: 75.6286

COIL: 0.7169

CONS_SCORE: 0.7425

DSS_SCORE: 0.1446

HELIX: 0.023

FCONS_SCORE: 0.9271

RIG_SCORE: 0.8054

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1759G	TCGA-AA-3984	COAD	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D1759G	DO9002	COAD	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.7198
p.S1760T	TCGA-AR-A256	BRCA	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1760T	DO4155	BRCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1746D	TCGA-DU-6407	LGG	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1746D	DO22295	LGG	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1764R	TCGA-EO-A22U	UCEC	TCGA	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764R	DO43755	UCEC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO230334	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO227999	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO229010	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO229013	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO229016	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO229005	COCA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO234285	ESAD	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO229505	LAML	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO230993	LUSC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1764V	DO230990	LUSC	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D1765N	DO220862	MELA	ICGC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1765E	SIDM00987	Thyroid Gland Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1765E	BHT-101	thyroid	COSMIC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.I1755M	SIDM00798	Rhabdomyosarcoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.6507
p.I1755M	SIDM00839	Colorectal Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.6507
p.L1749V	SIDM00336	Melanoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L1749V	SIDM00945	Colorectal Carcinoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L1749V	SIDM01101	Neuroblastoma	GDSC	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1746S	ACH-001634	Leukemia	CCLE	KGILHKD	LIG_APCC_ABBAyCdc20_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KGILHKD

Degron related mutations and impact score

Drug responses associated with F5 mutations

All proteins holding degron of KGILHKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12259	Coagulation factor V	LIG_APCC_ABBAyCdc20_2	1753:1759	KGILHKD	APC,CDC20,FZR1	0.5437	More...