DegronMD

Uniprot ID: P12259

Source protein: Coagulation factor V

Source gene: F5

Class: LIG_APCC_ABBA_1

Location: 1391:1396

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9649

ASA_SCORE: 79.6667

COIL: 0.8972

CONS_SCORE: 0.3974

DSS_SCORE: 0.4673

HELIX: 0.0685

FCONS_SCORE: 1.0153

RIG_SCORE: 0.7672

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1381K	TCGA-22-4613	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.0556
p.Q1381K	DO26468	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.0556
p.E1390Q	TCGA-34-2600	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.E1390Q	DO27081	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.S1385C	TCGA-56-8628	LUSC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.1667
p.S1385C	DO45433	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1667
p.P1392S	TCGA-86-6851	LUAD	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.5641
p.P1392S	TCGA-AX-A0J1	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.5641
p.P1392S	DO23798	LUAD	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.5641
p.P1392S	DO41199	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.5641
p.L1388I	TCGA-A5-A2K5	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.25
p.L1388I	DO41379	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.25
p.S1389N	TCGA-AN-A0FW	BRCA	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.2778
p.S1389N	DO2825	BRCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.2778
p.D1396E	TCGA-AP-A1DK	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.5647
p.D1396E	DO42033	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.5647
p.D1387Y	TCGA-B5-A1MR	UCEC	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.2222
p.D1387Y	DO41758	UCEC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.2222
p.S1385F	TCGA-EE-A2MC	SKCM	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.1667
p.S1385F	DO37559	SKCM	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1667
p.P1401S	TCGA-WE-A8K4	SKCM	TCGA	MPLFAD	LIG_APCC_ABBA_1	0.1944
p.P1401S	DO51281	SKCM	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1944
p.L1397F	DO229010	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.L1397F	DO229013	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.L1397F	DO229016	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.L1397F	DO229003	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.L1397F	DO229505	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.3056
p.P1404S	DO229013	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.P1404S	DO229016	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.P1404S	DO229005	COCA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.P1404S	DO230659	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.P1404S	DO231140	LAML	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.P1404S	DO230550	LUSC	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.1111
p.D1396H	DO233726	GACA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.7688
p.T1382I	DO220878	MELA	ICGC	MPLFAD	LIG_APCC_ABBA_1	0.0833
p.T1382I	SIDM01095	Rhabdomyosarcoma	GDSC	MPLFAD	LIG_APCC_ABBA_1	0.0833
p.T1382I	ACH-000833	Sarcoma	CCLE	MPLFAD	LIG_APCC_ABBA_1	0.0833
p.T1382I	SJRH30	soft_tissue	COSMIC	MPLFAD	LIG_APCC_ABBA_1	0.0833
p.T1387I	SJRH30	soft_tissue	COSMIC	MPLFAD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MPLFAD

Degron related mutations and impact score

Drug responses associated with F5 mutations

All proteins holding degron of MPLFAD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12259	Coagulation factor V	LIG_APCC_ABBA_1	1391:1396	MPLFAD	APC,CDC20,FZR1	0.9649	More...