DegronMD

Uniprot ID: P12259

Source protein: Coagulation factor V

Source gene: F5

Class: LIG_APCC_ABBAyCdc20_2

Location: 62:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5109

ASA_SCORE: 42.1

COIL: 0.0989

CONS_SCORE: 0.8724

DSS_SCORE: 0.1244

HELIX: 0.0067

FCONS_SCORE: 1.5527

RIG_SCORE: 0.8756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L56I	TCGA-AG-3892	READ	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	TCGA-AP-A059	UCEC	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	TCGA-BS-A0UF	UCEC	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	TCGA-EI-6917	READ	TCGA	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	DO36394	READ	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	DO36881	READ	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	DO41488	UCEC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L56I	DO41361	UCEC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P71Q	DO229027	LICA	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.L54F	DO26469	LUSC	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R67I	DO229224	THCA	ICGC	KKIVYRE	LIG_APCC_ABBAyCdc20_2	0.6991

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12259	Coagulation factor V	LIG_APCC_ABBAyCdc20_2	62:68	KKIVYRE	APC,CDC20,FZR1	0.5109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons