DegronMD

Uniprot ID: O60239

Source protein: SH3 domain-binding protein 5

Source gene: SH3BP5

Class: DEG_MDM2_SWIB_1

Location: 151:159

E3 ligase: MDM2

DEGRON score: 0.7553

ASA_SCORE: 57.6

COIL: 0.1916

CONS_SCORE: 0.6927

DSS_SCORE: 0.414

HELIX: 0.8002

FCONS_SCORE: 1.1895

RIG_SCORE: 0.7677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R165G	TCGA-CM-6171	COAD	TCGA	FDSAWQEML	DEG_MDM2_SWIB_1	0.1667
p.S155A	DO12382	GBM	ICGC	FDSAWQEML	DEG_MDM2_SWIB_1	0.7588
p.V154L	DO13114	GBM	ICGC	FDSAWQEML	DEG_MDM2_SWIB_1	0.6765
p.D147Y	DO232224	PBCA	ICGC	FDSAWQEML	DEG_MDM2_SWIB_1	0.2222
p.D147G	DO229253	THCA	ICGC	FDSAWQEML	DEG_MDM2_SWIB_1	0.2222
p.T163I	SIDM01945	Colorectal Carcinoma	GDSC	FDSAWQEML	DEG_MDM2_SWIB_1	0.2222
p.D146E	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FDSAWQEML	DEG_MDM2_SWIB_1	0.1944
p.D146E	ACH-000945	Lung Cancer	CCLE	FDSAWQEML	DEG_MDM2_SWIB_1	0.1944
p.D146E	NCI-H650	lung	COSMIC	FDSAWQEML	DEG_MDM2_SWIB_1	0.1944
p.R149W	SIDM01088	Endometrial Carcinoma	GDSC	FDSAWQEML	DEG_MDM2_SWIB_1	0.2778
p.S151T	IM-95	stomach	COSMIC	FDSAWQEML	DEG_MDM2_SWIB_1	0.7116
p.E146K	ESS-1	endometrium	COSMIC	FDSAWQEML	DEG_MDM2_SWIB_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60239	SH3 domain-binding protein 5	DEG_MDM2_SWIB_1	151:159	FDSAWQEML	MDM2	0.7553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons