DegronMD

Uniprot ID: A6NHR9

Source protein: Structural maintenance of chromosomes flexible hinge domain-containing protein 1

Source gene: SMCHD1

Class: DEG_MDM2_SWIB_1

Location: 472:480

E3 ligase: MDM2

DEGRON score: 0.5101

ASA_SCORE: 32.7111

COIL: 0.3119

CONS_SCORE: 0.7588

DSS_SCORE: 0.087

HELIX: 0.066

FCONS_SCORE: 1.5026

RIG_SCORE: 0.8921

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R466S	TCGA-19-1790	GBM	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	0.1667
p.R466S	DO12328	GBM	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	0.1667
p.S485P	TCGA-A5-A0G1	UCEC	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	0.1944
p.S485P	DO42472	UCEC	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	0.1944
p.R479Q	TCGA-AR-A0TX	BRCA	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	0.6218
p.R479Q	DO1663	BRCA	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	0.6218
p.R469M	DO233942	GACA	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHR9	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	DEG_MDM2_SWIB_1	472:480	FECFWNGRL	MDM2	0.5101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons