DegronMD - A6NHR9(SMCHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R466S	TCGA-19-1790	GBM	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation rewiring degron network	0.1667
p.R466S	DO12328	GBM	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation rewiring degron network	0.1667
p.L1513F	TCGA-50-5941	LUAD	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.0556
p.L1513F	DO25528	LUAD	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.0556
p.V1492A	TCGA-99-7458	LUAD	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.1944
p.V1492A	DO25416	LUAD	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.1944
p.S485P	TCGA-A5-A0G1	UCEC	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation rewiring degron network	0.1944
p.S485P	DO42472	UCEC	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation rewiring degron network	0.1944
p.R479Q	TCGA-AR-A0TX	BRCA	TCGA	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation altering degron motif	0.6218
p.R479Q	DO1663	BRCA	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation altering degron motif	0.6218
p.N1504Y	TCGA-DD-AACQ	LIHC	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.3056
p.N1504Y	DO52211	LIHC	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.3056
p.R1506C	TCGA-FR-A726	SKCM	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.25
p.R1506C	DO48665	SKCM	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.25
p.R1506H	TCGA-GN-A268	SKCM	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.25
p.R1506H	DO37477	SKCM	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.25
p.S1507L	TCGA-GU-AATO	BLCA	TCGA	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation blocking phosphorylation signal	0.6667
p.S1507L	DO51893	BLCA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation blocking phosphorylation signal	0.6667
p.N1504S	DO233708	GACA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.3056
p.R469M	DO233942	GACA	ICGC	FECFWNGRL	DEG_MDM2_SWIB_1	472:480	Mutation rewiring degron network	0.25
p.S1510I	DO229034	LICA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation rewiring degron network	0.1389
p.P1498H	SIDM00333	Endometrial Carcinoma	GDSC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation altering degron motif	0.6583
p.P1498H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation altering degron motif	0.6583
p.P1498H	MFE-319	endometrium	COSMIC	PPTPAVS	DEG_SCF_FBW7_1	1497:1503	Mutation altering degron motif	0.6583

Kaplan plot for SMCHD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMCHD1

UniProt ID: A6NHR9

Entrez ID: 23347

Protein name: Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMCHD1 in