DegronMD

Uniprot ID: A6NHR9

Source protein: Structural maintenance of chromosomes flexible hinge domain-containing protein 1

Source gene: SMCHD1

Class: DEG_SCF_FBW7_1

Location: 1497:1503

E3 ligase: FBXW7

DEGRON score: 0.5349

ASA_SCORE: 64.9857

COIL: 0.7244

CONS_SCORE: 0.4014

DSS_SCORE: 0.3871

HELIX: 0.0394

FCONS_SCORE: 0.8506

RIG_SCORE: 0.7146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1513F	TCGA-50-5941	LUAD	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.0556
p.L1513F	DO25528	LUAD	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.0556
p.V1492A	TCGA-99-7458	LUAD	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.1944
p.V1492A	DO25416	LUAD	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.1944
p.N1504Y	TCGA-DD-AACQ	LIHC	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.3056
p.N1504Y	DO52211	LIHC	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.3056
p.R1506C	TCGA-FR-A726	SKCM	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.25
p.R1506C	DO48665	SKCM	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.25
p.R1506H	TCGA-GN-A268	SKCM	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.25
p.R1506H	DO37477	SKCM	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.25
p.S1507L	TCGA-GU-AATO	BLCA	TCGA	PPTPAVS	DEG_SCF_FBW7_1	0.6667
p.S1507L	DO51893	BLCA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.6667
p.N1504S	DO233708	GACA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.3056
p.S1510I	DO229034	LICA	ICGC	PPTPAVS	DEG_SCF_FBW7_1	0.1389
p.P1498H	SIDM00333	Endometrial Carcinoma	GDSC	PPTPAVS	DEG_SCF_FBW7_1	0.6583
p.P1498H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPAVS	DEG_SCF_FBW7_1	0.6583
p.P1498H	MFE-319	endometrium	COSMIC	PPTPAVS	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHR9	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	DEG_SCF_FBW7_1	1497:1503	PPTPAVS	FBXW7	0.5349	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons