DegronMD

Uniprot ID: Q9NZ71

Source protein: Regulator of telomere elongation helicase 1

Source gene: RTEL1

Class: LIG_APCC_ABBA_1

Location: 349:354

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8612

ASA_SCORE: 50.4833

COIL: 0.047

CONS_SCORE: 0.45

DSS_SCORE: 0.0979

HELIX: 0.9515

FCONS_SCORE: 1.1669

RIG_SCORE: 0.943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K343N	TCGA-D1-A176	UCEC	TCGA	FELFAE	LIG_APCC_ABBA_1	0.2778
p.K343N	TCGA-GN-A262	SKCM	TCGA	FELFAE	LIG_APCC_ABBA_1	0.2778
p.G351E	TCGA-E2-A105	BRCA	TCGA	FELFAE	LIG_APCC_ABBA_1	0.7199
p.E357Q	TCGA-E2-A105	BRCA	TCGA	FELFAE	LIG_APCC_ABBA_1	0.25
p.L346M	TCGA-EE-A2M8	SKCM	TCGA	FELFAE	LIG_APCC_ABBA_1	0.25
p.D354N	TCGA-EO-A22U	UCEC	TCGA	FELFAE	LIG_APCC_ABBA_1	0.6932
p.E350K	TCGA-GU-AATO	BLCA	TCGA	FELFAE	LIG_APCC_ABBA_1	0.591
p.G360R	TCGA-LN-A9FP	ESCA	TCGA	FELFAE	LIG_APCC_ABBA_1	0.1667
p.G345W	DO228948	LICA	ICGC	FELFAE	LIG_APCC_ABBA_1	0.2222
p.A355S	DO43186	UCEC	ICGC	FELFAE	LIG_APCC_ABBA_1	0.3056
p.Y340N	NCI-H1304	lung	COSMIC	FELFAE	LIG_APCC_ABBA_1	0.0833
p.D361N	HT-115	large_intestine	COSMIC	FELFAE	LIG_APCC_ABBA_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ71	Regulator of telomere elongation helicase 1	LIG_APCC_ABBA_1	349:354	FELFAE	APC,CDC20,FZR1	0.8612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons