DegronMD - Q9NZ71(RTEL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D427N	TCGA-06-0173	GBM	TCGA	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.6932
p.D427N	TCGA-06-0173	GBM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation altering degron motif	0.6932
p.D427N	TCGA-55-8087	LUAD	TCGA	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.6932
p.D427N	TCGA-55-8087	LUAD	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation altering degron motif	0.6932
p.Q825H	TCGA-55-7907	LUAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1667
p.S822R	TCGA-63-A5MS	LUSC	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.0833
p.S822R	HCC1569	breast	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.0833
p.E430D	TCGA-69-7979	LUAD	TCGA	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2778
p.E430D	TCGA-69-7979	LUAD	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2778
p.F807L	TCGA-93-8067	LUAD	TCGA	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1111
p.V798A	TCGA-AZ-6601	COAD	TCGA	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.6936
p.G834V	TCGA-BQ-7049	KIRP	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.7532
p.G794R	TCGA-D1-A0ZO	UCEC	TCGA	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.7568
p.K343N	TCGA-D1-A176	UCEC	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation substituting flanking lysine	0.2778
p.K343N	TCGA-GN-A262	SKCM	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation substituting flanking lysine	0.2778
p.S435F	TCGA-D3-A2JH	SKCM	TCGA	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1389
p.S435F	TCGA-D3-A2JH	SKCM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1389
p.P804L	TCGA-DM-A28F	COAD	TCGA	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1944
p.G351E	TCGA-E2-A105	BRCA	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation altering degron motif	0.7199
p.E357Q	TCGA-E2-A105	BRCA	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.25
p.L346M	TCGA-EE-A2M8	SKCM	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.25
p.S429F	TCGA-EE-A3AG	SKCM	TCGA	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.S429F	TCGA-EE-A3AG	SKCM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.3056
p.R786W	TCGA-EK-A2RA	CESC	TCGA	SLDLHVPSL	DEG_COP1_1	791:799	Mutation blocking phosphorylation signal	0.6389
p.D354N	TCGA-EO-A22U	UCEC	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation altering degron motif	0.6932
p.A833T	TCGA-G4-6588	COAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.7139
p.E350K	TCGA-GU-AATO	BLCA	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation altering degron motif	0.591
p.G829R	TCGA-IB-7651	PAAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.2778
p.G360R	TCGA-LN-A9FP	ESCA	TCGA	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.1667
p.P836S	TCGA-NJ-A4YI	LUAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.6752
p.A809T	DO10140	COAD	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.0556
p.K790N	DO15599	HNSC	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.3056
p.R844Q	DO49743	KIRP	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1944
p.G345W	DO228948	LICA	ICGC	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.2222
p.G781V	DO228974	LICA	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.0556
p.S841I	DO228986	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.2778
p.E823D	DO229025	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1111
p.G849C	DO229041	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.0556
p.A836D	DO22866	LIHC	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.6682
p.F783L	DO25113	LUAD	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1111
p.Q801H	DO25396	LUAD	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.2778
p.A845S	DO26740	LUSC	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1667
p.S798R	DO219161	LUSC	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.8538
p.S798R	SIDM00878	Breast Carcinoma	GDSC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.8538
p.S798R	ACH-000930	Breast Cancer	CCLE	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.8538
p.S798R	HCC1569	breast	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.8538
p.H840D	DO232838	NACA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.3056
p.G805R	DO46657	PAAD	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1667
p.A789V	DO51499	PACA	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.2778
p.E842K	DO36556	READ	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.G416W	DO37835	SKCM	ICGC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1389
p.G416W	DO37835	SKCM	ICGC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.R787M	DO37407	SKCM	ICGC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.2222
p.A355S	DO43186	UCEC	ICGC	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.3056
p.R437Q	SIDM01281	Colorectal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.0833
p.R437Q	SIDM01281	Colorectal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.0833
p.T434M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00303	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00303	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00353	Other Sarcomas	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00353	Other Sarcomas	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00584	Osteosarcoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00584	Osteosarcoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00491	Thyroid Gland Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00491	Thyroid Gland Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00291	Melanoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00291	Melanoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00581	Glioblastoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00581	Glioblastoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00589	Oral Cavity Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00589	Oral Cavity Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00533	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00533	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00530	Esophageal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00530	Esophageal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00238	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00238	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00568	Gastric Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00568	Gastric Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00301	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00301	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00599	Osteosarcoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00599	Osteosarcoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00487	Colorectal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00487	Colorectal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00252	Biliary Tract Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00252	Biliary Tract Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00567	Other Solid Cancers	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00567	Other Solid Cancers	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00302	Other Solid Cancers	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00302	Other Solid Cancers	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01659	Kidney Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01659	Kidney Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00008	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM00008	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01588	Endometrial Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01588	Endometrial Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01619	Endometrial Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.T434M	SIDM01619	Endometrial Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.S806L	SIDM01113	Other Sarcomas	GDSC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1389
p.S806L	ACH-000939	Sarcoma	CCLE	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1389
p.R432W	SIDM01469	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.R432W	SIDM01469	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.R432W	ACH-000085	Pancreatic Cancer	CCLE	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.R432W	ACH-000085	Pancreatic Cancer	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.R432Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.R432Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.R432Q	ACH-000782	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.R432Q	ACH-000782	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.R432Q	ACH-001735	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.R432Q	ACH-001735	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.R828W	ACH-000419	Myeloma	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.R828W	ACH-001541	Myeloma	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.H795Y	ACH-000437	Brain Cancer	CCLE	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.6118
p.P427S	ACH-001127	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.5641
p.P427S	ACH-001127	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation altering degron motif	0.5641
p.P427S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.5641
p.P427S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation altering degron motif	0.5641
p.H424Y	ACH-001369	Ovarian Cancer	CCLE	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.6118
p.H424Y	ACH-001369	Ovarian Cancer	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation altering degron motif	0.6118
p.S841N	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.2778
p.R828Q	ACH-001845	Bile Duct Cancer	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.Y340N	NCI-H1304	lung	COSMIC	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation rewiring degron network	0.0833
p.G434C	HSC-2	upper aerodigestive tract	COSMIC	VHIHPD	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1667
p.G434C	HSC-2	upper aerodigestive tract	COSMIC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1667
p.L799V	TGBC24TKB	biliary tract	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.5654
p.L799V	KO52	haematopoietic and lymphoid tissue	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.5654
p.L799V	NCI-SNU-16	stomach	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.5654
p.L799V	LU-134-A	lung	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation altering degron motif	0.5654
p.R845H	AN3-CA	endometrium	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1667
p.R828T	H513	pleura	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.D361N	HT-115	large intestine	COSMIC	FELFAE	LIG_APCC_ABBA_1	349:354	Mutation blocking phosphorylation signal	0.5833
p.A784P	IGROV-1	ovary	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1389
p.S807L	PEO1	ovary	COSMIC	SLDLHVPSL	DEG_COP1_1	791:799	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTEL1

UniProt ID: Q9NZ71

Entrez ID: 51750

Protein name: Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTEL1 in