DegronMD

Uniprot ID: Q9NZ71

Source protein: Regulator of telomere elongation helicase 1

Source gene: RTEL1

Class: DEG_COP1_1

Location: 791:799

E3 ligase: COP1

DEGRON score: 0.999

ASA_SCORE: 80.1778

COIL: 0.7786

CONS_SCORE: 0.2665

DSS_SCORE: 0.5383

HELIX: 0.1623

FCONS_SCORE: 1.1631

RIG_SCORE: 0.713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F807L	TCGA-93-8067	LUAD	TCGA	SLDLHVPSL	DEG_COP1_1	0.1111
p.V798A	TCGA-AZ-6601	COAD	TCGA	SLDLHVPSL	DEG_COP1_1	0.6936
p.G794R	TCGA-D1-A0ZO	UCEC	TCGA	SLDLHVPSL	DEG_COP1_1	0.7568
p.P804L	TCGA-DM-A28F	COAD	TCGA	SLDLHVPSL	DEG_COP1_1	0.1944
p.R786W	TCGA-EK-A2RA	CESC	TCGA	SLDLHVPSL	DEG_COP1_1	0.6389
p.A809T	DO10140	COAD	ICGC	SLDLHVPSL	DEG_COP1_1	0.0556
p.K790N	DO15599	HNSC	ICGC	SLDLHVPSL	DEG_COP1_1	0.3056
p.G781V	DO228974	LICA	ICGC	SLDLHVPSL	DEG_COP1_1	0.0556
p.F783L	DO25113	LUAD	ICGC	SLDLHVPSL	DEG_COP1_1	0.1111
p.Q801H	DO25396	LUAD	ICGC	SLDLHVPSL	DEG_COP1_1	0.2778
p.S798R	DO219161	LUSC	ICGC	SLDLHVPSL	DEG_COP1_1	0.8538
p.S798R	SIDM00878	Breast Carcinoma	GDSC	SLDLHVPSL	DEG_COP1_1	0.8538
p.S798R	ACH-000930	Breast Cancer	CCLE	SLDLHVPSL	DEG_COP1_1	0.8538
p.S798R	HCC1569	breast	COSMIC	SLDLHVPSL	DEG_COP1_1	0.8538
p.G805R	DO46657	PAAD	ICGC	SLDLHVPSL	DEG_COP1_1	0.1667
p.A789V	DO51499	PACA	ICGC	SLDLHVPSL	DEG_COP1_1	0.2778
p.R787M	DO37407	SKCM	ICGC	SLDLHVPSL	DEG_COP1_1	0.2222
p.S806L	SIDM01113	Other Sarcomas	GDSC	SLDLHVPSL	DEG_COP1_1	0.1389
p.S806L	ACH-000939	Sarcoma	CCLE	SLDLHVPSL	DEG_COP1_1	0.1389
p.H795Y	ACH-000437	Brain Cancer	CCLE	SLDLHVPSL	DEG_COP1_1	0.6118
p.L799V	TGBC24TKB	biliary_tract	COSMIC	SLDLHVPSL	DEG_COP1_1	0.5654
p.L799V	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	SLDLHVPSL	DEG_COP1_1	0.5654
p.L799V	NCI-SNU-16	stomach	COSMIC	SLDLHVPSL	DEG_COP1_1	0.5654
p.L799V	LU-134-A	lung	COSMIC	SLDLHVPSL	DEG_COP1_1	0.5654
p.A784P	IGROV-1	ovary	COSMIC	SLDLHVPSL	DEG_COP1_1	0.1389
p.S807L	PEO1	ovary	COSMIC	SLDLHVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ71	Regulator of telomere elongation helicase 1	DEG_COP1_1	791:799	SLDLHVPSL	COP1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons