DegronMD

Uniprot ID: Q9NZ71

Source protein: Regulator of telomere elongation helicase 1

Source gene: RTEL1

Class: DEG_APCC_DBOX_1

Location: 831:839

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 78.2556

COIL: 0.4762

CONS_SCORE: 0.2855

DSS_SCORE: 0.6311

HELIX: 0.4921

FCONS_SCORE: 1.248

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q825H	TCGA-55-7907	LUAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.1667
p.S822R	TCGA-63-A5MS	LUSC	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.0833
p.S822R	HCC1569	breast	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	0.0833
p.G834V	TCGA-BQ-7049	KIRP	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.7532
p.A833T	TCGA-G4-6588	COAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.7139
p.G829R	TCGA-IB-7651	PAAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.2778
p.P836S	TCGA-NJ-A4YI	LUAD	TCGA	PRGLLAALE	DEG_APCC_DBOX_1	0.6752
p.R844Q	DO49743	KIRP	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.1944
p.S841I	DO228986	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.2778
p.E823D	DO229025	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.1111
p.G849C	DO229041	LICA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.0556
p.A836D	DO22866	LIHC	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.6682
p.A845S	DO26740	LUSC	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.1667
p.H840D	DO232838	NACA	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.3056
p.E842K	DO36556	READ	ICGC	PRGLLAALE	DEG_APCC_DBOX_1	0.25
p.R828W	ACH-000419	Myeloma	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	0.25
p.R828W	ACH-001541	Myeloma	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	0.25
p.S841N	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	0.2778
p.R828Q	ACH-001845	Bile Duct Cancer	CCLE	PRGLLAALE	DEG_APCC_DBOX_1	0.25
p.R845H	AN3-CA	endometrium	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	0.1667
p.R828T	H513	pleura	COSMIC	PRGLLAALE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ71	Regulator of telomere elongation helicase 1	DEG_APCC_DBOX_1	831:839	PRGLLAALE	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons