DegronMD

Uniprot ID: Q9NZ71

Source protein: Regulator of telomere elongation helicase 1

Source gene: RTEL1

Class: LIG_APCC_ABBA_1

Location: 423:428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9026

ASA_SCORE: 55.1

COIL: 0.443

CONS_SCORE: 0.411

DSS_SCORE: 0.494

HELIX: 0.1327

FCONS_SCORE: 1.402

RIG_SCORE: 0.7235

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D427N	TCGA-06-0173	GBM	TCGA	VHIHPD	LIG_APCC_ABBA_1	0.6932
p.D427N	TCGA-55-8087	LUAD	TCGA	VHIHPD	LIG_APCC_ABBA_1	0.6932
p.E430D	TCGA-69-7979	LUAD	TCGA	VHIHPD	LIG_APCC_ABBA_1	0.2778
p.S435F	TCGA-D3-A2JH	SKCM	TCGA	VHIHPD	LIG_APCC_ABBA_1	0.1389
p.S429F	TCGA-EE-A3AG	SKCM	TCGA	VHIHPD	LIG_APCC_ABBA_1	0.3056
p.G416W	DO37835	SKCM	ICGC	VHIHPD	LIG_APCC_ABBA_1	0.1389
p.R437Q	SIDM01281	Colorectal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.0833
p.T434M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00303	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00353	Other Sarcomas	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00584	Osteosarcoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00491	Thyroid Gland Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00291	Melanoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00581	Glioblastoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00589	Oral Cavity Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00533	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00530	Esophageal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00238	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00568	Gastric Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00301	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00599	Osteosarcoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00487	Colorectal Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00252	Biliary Tract Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00567	Other Solid Cancers	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00302	Other Solid Cancers	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM01659	Kidney Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM00008	Ovarian Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM01588	Endometrial Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.T434M	SIDM01619	Endometrial Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.1667
p.R432W	SIDM01469	Pancreatic Carcinoma	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.2222
p.R432W	ACH-000085	Pancreatic Cancer	CCLE	VHIHPD	LIG_APCC_ABBA_1	0.2222
p.R432Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VHIHPD	LIG_APCC_ABBA_1	0.2222
p.R432Q	ACH-000782	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	0.2222
p.R432Q	ACH-001735	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	0.2222
p.P427S	ACH-001127	Leukemia	CCLE	VHIHPD	LIG_APCC_ABBA_1	0.5641
p.P427S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VHIHPD	LIG_APCC_ABBA_1	0.5641
p.H424Y	ACH-001369	Ovarian Cancer	CCLE	VHIHPD	LIG_APCC_ABBA_1	0.6118
p.G434C	HSC-2	upper_aerodigestive_tract	COSMIC	VHIHPD	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHIHPD

Degron related mutations and impact score

Drug responses associated with RTEL1 mutations

All proteins holding degron of VHIHPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ71	Regulator of telomere elongation helicase 1	LIG_APCC_ABBA_1	423:428	VHIHPD	APC,CDC20,FZR1	0.9026	More...