DegronMD

Uniprot ID: Q9NZ71

Source protein: Regulator of telomere elongation helicase 1

Source gene: RTEL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 422:428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9434

ASA_SCORE: 55.7429

COIL: 0.3986

CONS_SCORE: 0.4184

DSS_SCORE: 0.4923

HELIX: 0.1443

FCONS_SCORE: 1.483

RIG_SCORE: 0.7252

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D427N	TCGA-06-0173	GBM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D427N	TCGA-55-8087	LUAD	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E430D	TCGA-69-7979	LUAD	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S435F	TCGA-D3-A2JH	SKCM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S429F	TCGA-EE-A3AG	SKCM	TCGA	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G416W	DO37835	SKCM	ICGC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R437Q	SIDM01281	Colorectal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T434M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00303	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00353	Other Sarcomas	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00584	Osteosarcoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00491	Thyroid Gland Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00291	Melanoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00581	Glioblastoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00589	Oral Cavity Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00533	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00530	Esophageal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00238	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00568	Gastric Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00301	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00599	Osteosarcoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00487	Colorectal Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00252	Biliary Tract Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00567	Other Solid Cancers	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00302	Other Solid Cancers	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM01659	Kidney Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM00008	Ovarian Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM01588	Endometrial Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T434M	SIDM01619	Endometrial Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R432W	SIDM01469	Pancreatic Carcinoma	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R432W	ACH-000085	Pancreatic Cancer	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R432Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R432Q	ACH-000782	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R432Q	ACH-001735	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P427S	ACH-001127	Leukemia	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P427S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.5641
p.H424Y	ACH-001369	Ovarian Cancer	CCLE	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.6118
p.G434C	HSC-2	upper_aerodigestive_tract	COSMIC	KVHIHPD	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KVHIHPD

Degron related mutations and impact score

Drug responses associated with RTEL1 mutations

All proteins holding degron of KVHIHPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ71	Regulator of telomere elongation helicase 1	LIG_APCC_ABBAyCdc20_2	422:428	KVHIHPD	APC,CDC20,FZR1	0.9434	More...