DegronMD

Uniprot ID: Q9Y4F1

Source protein: FERM, ARHGEF and pleckstrin domain-containing protein 1

Source gene: FARP1

Class: LIG_APCC_ABBA_1

Location: 779:784

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6418

ASA_SCORE: 25.45

COIL: 0.279

CONS_SCORE: 0.5399

DSS_SCORE: 0.0238

HELIX: 0.1972

FCONS_SCORE: 1.3423

RIG_SCORE: 0.9712

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R782M	DO233888	GACA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.8632
p.R783S	DO229037	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.7427
p.Y788C	TCGA-DI-A1BU	UCEC	TCGA	FFLFND	LIG_APCC_ABBA_1	0.6667
p.Y788C	DO42023	UCEC	ICGC	FFLFND	LIG_APCC_ABBA_1	0.6667
p.V788L	DO229018	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.6667
p.C778Y	DO52404	UCEC	ICGC	FFLFND	LIG_APCC_ABBA_1	0.3056
p.V785I	ACH-000920	Leukemia	CCLE	FFLFND	LIG_APCC_ABBA_1	0.3056
p.V785I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FFLFND	LIG_APCC_ABBA_1	0.3056
p.R777L	DO228926	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.2778
p.R777C	DO232224	PBCA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.2778
p.R775H	DO45317	LUAD	ICGC	FFLFND	LIG_APCC_ABBA_1	0.2222
p.R775H	DO228138	PBCA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.2222
p.R774S	DO228905	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	0.1944
p.A773V	SIDM00683	Prostate Carcinoma	GDSC	FFLFND	LIG_APCC_ABBA_1	0.1667
p.R791Q	TCGA-HU-A4GQ	STAD	TCGA	FFLFND	LIG_APCC_ABBA_1	0.1389
p.R791Q	DO47767	STAD	ICGC	FFLFND	LIG_APCC_ABBA_1	0.1389
p.R791Q	ACH-000874	Leukemia	CCLE	FFLFND	LIG_APCC_ABBA_1	0.1389
p.R791Q	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	FFLFND	LIG_APCC_ABBA_1	0.1389
p.R791W	TCGA-RQ-A68N	DLBC	TCGA	FFLFND	LIG_APCC_ABBA_1	0.1389
p.R791W	DO219921	DLBC	ICGC	FFLFND	LIG_APCC_ABBA_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F1	FERM, ARHGEF and pleckstrin domain-containing protein 1	LIG_APCC_ABBA_1	779:784	FFLFND	APC,CDC20,FZR1	0.6418	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons