DegronMD - Q9Y4F1(FARP1)

FUNCTION: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.

GO - Biological processes (BP): dendrite morphogenesis [GO:0048813]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of presynapse assembly [GO:1905606]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; synapse assembly [GO:0007416]

GO - Molecular function (MF): cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]

GO - Cellular component (CC): cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R782M	DO233888	GACA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation altering degron motif	0.8632
p.R783S	DO229037	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation altering degron motif	0.7427
p.Y788C	TCGA-DI-A1BU	UCEC	TCGA	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation blocking phosphorylation signal	0.6667
p.Y788C	DO42023	UCEC	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation blocking phosphorylation signal	0.6667
p.V788L	DO229018	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation blocking phosphorylation signal	0.6667
p.D558Y	DO228985	LICA	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.6214
p.C778Y	DO52404	UCEC	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.3056
p.V785I	ACH-000920	Leukemia	CCLE	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.3056
p.V785I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.3056
p.R777L	DO228926	LICA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.2778
p.R777C	DO232224	PBCA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.2778
p.K546E	DO46847	RECA	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation substituting flanking lysine	0.2778
p.S564L	TCGA-AA-A00N	COAD	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.S564L	TCGA-W3-AA1Q	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.S564L	DO9876	COAD	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.S564L	DO219487	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.S564P	TCGA-BF-A1Q0	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.S564P	DO47374	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.R775H	DO45317	LUAD	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.2222
p.R775H	DO228138	PBCA	ICGC	FFLFND	LIG_APCC_ABBA_1	779:784	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 31 entries

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No resistance data available for this Degron.

Kaplan plot for FARP1 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

FARP1

UniProt ID: Q9Y4F1

Entrez ID: 10160

Protein name: FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for FARP1 in