DegronMD

Uniprot ID: Q9Y4F1

Source protein: FERM, ARHGEF and pleckstrin domain-containing protein 1

Source gene: FARP1

Class: DEG_APCC_DBOX_1

Location: 552:560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7527

ASA_SCORE: 68.7222

COIL: 0.3631

CONS_SCORE: 0.5306

DSS_SCORE: 0.1503

HELIX: 0.493

FCONS_SCORE: 1.3203

RIG_SCORE: 0.8895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S564L	TCGA-AA-A00N	COAD	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.S564L	TCGA-W3-AA1Q	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.S564L	DO9876	COAD	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.S564L	DO219487	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.A545T	TCGA-AP-A051	UCEC	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.1389
p.A545T	DO42673	UCEC	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.1389
p.S564P	TCGA-BF-A1Q0	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.S564P	DO47374	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.2222
p.D558Y	DO228985	LICA	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.6214
p.A545S	DO229038	LICA	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.1389
p.K546E	DO46847	RECA	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94887	FERM, ARHGEF and pleckstrin domain-containing protein 2	DEG_APCC_DBOX_1	547:555	ERTYLKDLE	APC,CDC20,FZR1	0.8569	More...
Q9Y4F1	FERM, ARHGEF and pleckstrin domain-containing protein 1	DEG_APCC_DBOX_1	552:560	ERTYLKDLE	APC,CDC20,FZR1	0.7527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons