DegronMD - O94887(FARP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A564S	TCGA-22-5473	LUSC	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.0833
p.A564S	DO26467	LUSC	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.0833
p.R562C	TCGA-AP-A1DV	UCEC	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.1389
p.R562C	DO43186	UCEC	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.1389
p.A405D	TCGA-DF-A2KZ	UCEC	TCGA	NAFYSLSP	CBL_PTK	404:411	Mutation altering degron motif	0.6682
p.A405D	DO52409	UCEC	ICGC	NAFYSLSP	CBL_PTK	404:411	Mutation altering degron motif	0.6682
p.S428F	TCGA-FR-A726	SKCM	TCGA	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation blocking phosphorylation signal	0.5278
p.S428F	DO48665	SKCM	ICGC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation blocking phosphorylation signal	0.5278
p.T558I	TCGA-FS-A1ZC	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.25
p.T558I	DO37487	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.25
p.A403V	DO222877	COCA	ICGC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation rewiring degron network	0.1389
p.A403V	DO222877	COCA	ICGC	NAFYSLSP	CBL_PTK	404:411	Mutation rewiring degron network	0.3056
p.A403V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation rewiring degron network	0.1389
p.A403V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	NAFYSLSP	CBL_PTK	404:411	Mutation rewiring degron network	0.3056
p.A403V	ACH-001127	Leukemia	CCLE	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation rewiring degron network	0.1389
p.A403V	ACH-001127	Leukemia	CCLE	NAFYSLSP	CBL_PTK	404:411	Mutation rewiring degron network	0.3056
p.A403V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation rewiring degron network	0.1389
p.A403V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	NAFYSLSP	CBL_PTK	404:411	Mutation rewiring degron network	0.3056
p.L414V	DO52365	LUSC	ICGC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM00194	Colorectal Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM00352	Ovarian Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM00986	Head and Neck Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM01612	Endometrial Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM00169	Head and Neck Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.L414V	SIDM01578	Bladder Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	410:419	Mutation altering degron motif	0.5654
p.A564T	SIDM01117	Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.0833
p.V556I	SIDM00127	Oral Cavity Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM00761	Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM01097	Other Solid Cancers	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM00132	Pancreatic Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM00975	Melanoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.V556I	SIDM00115	Head and Neck Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation rewiring degron network	0.3056
p.D553Y	SIDM00663	Melanoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation altering degron motif	0.6214
p.D553Y	ACH-000814	Skin Cancer	CCLE	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation altering degron motif	0.6214
p.D553Y	Hs939-T	skin	COSMIC	ERTYLKDLE	DEG_APCC_DBOX_1	547:555	Mutation altering degron motif	0.6214

Kaplan plot for FARP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FARP2

UniProt ID: O94887

Entrez ID: 9855

Protein name: FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FARP2 in