DegronMD

Uniprot ID: O94887

Source protein: FERM, ARHGEF and pleckstrin domain-containing protein 2

Source gene: FARP2

Class: DEG_COP1_1

Location: 410:419

E3 ligase: COP1

DEGRON score: 0.9991

ASA_SCORE: 74.95

COIL: 0.9305

CONS_SCORE: 0.3723

DSS_SCORE: 0.3859

HELIX: 0.034

FCONS_SCORE: 1.0656

RIG_SCORE: 0.6686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S428F	TCGA-FR-A726	SKCM	TCGA	SPSTLVPSGL	DEG_COP1_1	0.5278
p.S428F	DO48665	SKCM	ICGC	SPSTLVPSGL	DEG_COP1_1	0.5278
p.A403V	DO222877	COCA	ICGC	SPSTLVPSGL	DEG_COP1_1	0.1389
p.A403V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPSTLVPSGL	DEG_COP1_1	0.1389
p.A403V	ACH-001127	Leukemia	CCLE	SPSTLVPSGL	DEG_COP1_1	0.1389
p.A403V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPSTLVPSGL	DEG_COP1_1	0.1389
p.L414V	DO52365	LUSC	ICGC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM00194	Colorectal Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM00352	Ovarian Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM00986	Head and Neck Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM01612	Endometrial Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM00169	Head and Neck Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654
p.L414V	SIDM01578	Bladder Carcinoma	GDSC	SPSTLVPSGL	DEG_COP1_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94887	FERM, ARHGEF and pleckstrin domain-containing protein 2	DEG_COP1_1	410:419	SPSTLVPSGL	COP1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons