DegronMD

Uniprot ID: O94887

Source protein: FERM, ARHGEF and pleckstrin domain-containing protein 2

Source gene: FARP2

Class: DEG_APCC_DBOX_1

Location: 547:555

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8569

ASA_SCORE: 74.8222

COIL: 0.3647

CONS_SCORE: 0.62

DSS_SCORE: 0.0209

HELIX: 0.4176

FCONS_SCORE: 1.2551

RIG_SCORE: 0.9416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A564S	TCGA-22-5473	LUSC	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.0833
p.A564S	DO26467	LUSC	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.0833
p.R562C	TCGA-AP-A1DV	UCEC	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.1389
p.R562C	DO43186	UCEC	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.1389
p.T558I	TCGA-FS-A1ZC	SKCM	TCGA	ERTYLKDLE	DEG_APCC_DBOX_1	0.25
p.T558I	DO37487	SKCM	ICGC	ERTYLKDLE	DEG_APCC_DBOX_1	0.25
p.A564T	SIDM01117	Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.0833
p.V556I	SIDM00127	Oral Cavity Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM00761	Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM01097	Other Solid Cancers	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM00132	Pancreatic Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM00975	Melanoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.V556I	SIDM00115	Head and Neck Carcinoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.3056
p.D553Y	SIDM00663	Melanoma	GDSC	ERTYLKDLE	DEG_APCC_DBOX_1	0.6214
p.D553Y	ACH-000814	Skin Cancer	CCLE	ERTYLKDLE	DEG_APCC_DBOX_1	0.6214
p.D553Y	Hs939-T	skin	COSMIC	ERTYLKDLE	DEG_APCC_DBOX_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94887	FERM, ARHGEF and pleckstrin domain-containing protein 2	DEG_APCC_DBOX_1	547:555	ERTYLKDLE	APC,CDC20,FZR1	0.8569	More...
Q9Y4F1	FERM, ARHGEF and pleckstrin domain-containing protein 1	DEG_APCC_DBOX_1	552:560	ERTYLKDLE	APC,CDC20,FZR1	0.7527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons