DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NAFYSLSP
Uniprot ID:
O94887
Source protein:
FERM, ARHGEF and pleckstrin domain-containing protein 2
Source gene:
FARP2
Class:
CBL_PTK
Location:
404:411
E3 ligase:
CBL
DEGRON score:
0.7814
ASA_SCORE:
83.425
COIL:
0.754
CONS_SCORE:
0.3351
DSS_SCORE:
0.396
HELIX:
0.1916
FCONS_SCORE:
0.8995
RIG_SCORE:
0.6899
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A405D
TCGA-DF-A2KZ
UCEC
TCGA
NAFYSLSP
CBL_PTK
0.6682
p.A405D
DO52409
UCEC
ICGC
NAFYSLSP
CBL_PTK
0.6682
p.A403V
DO222877
COCA
ICGC
NAFYSLSP
CBL_PTK
0.3056
p.A403V
SIDM00145
T-Lymphoblastic Leukemia
GDSC
NAFYSLSP
CBL_PTK
0.3056
p.A403V
ACH-001127
Leukemia
CCLE
NAFYSLSP
CBL_PTK
0.3056
p.A403V
MOLT-4
haematopoietic_and_lymphoid_tissue
COSMIC
NAFYSLSP
CBL_PTK
0.3056
Drug responses associated with FARP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NAFYSLSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94887
FERM, ARHGEF and pleckstrin domain-containing protein 2
CBL_PTK
404:411
NAFYSLSP
CBL
0.7814
More...
