DegronMD

Uniprot ID: Q03591

Source protein: Complement factor H-related protein 1

Source gene: CFHR1

Class: LIG_APCC_ABBA_1

Location: 88:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6298

ASA_SCORE: 80.9833

COIL: 0.7588

CONS_SCORE: 0.733

DSS_SCORE: 0.1493

HELIX: 0.0237

FCONS_SCORE: 0.8971

RIG_SCORE: 0.8661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V92L	TCGA-17-Z045	LUAD	TCGA	FFPFVE	LIG_APCC_ABBA_1	0.5654
p.G95C	TCGA-66-2770	LUSC	TCGA	FFPFVE	LIG_APCC_ABBA_1	0.2778
p.G95C	DO27556	LUSC	ICGC	FFPFVE	LIG_APCC_ABBA_1	0.2778
p.P90H	TCGA-AZ-4315	COAD	TCGA	FFPFVE	LIG_APCC_ABBA_1	0.7694
p.P90H	DO8842	COAD	ICGC	FFPFVE	LIG_APCC_ABBA_1	0.7694
p.G101V	DO229024	LICA	ICGC	FFPFVE	LIG_APCC_ABBA_1	0.1111
p.T80P	DO52682	MALY	ICGC	FFPFVE	LIG_APCC_ABBA_1	0.1111
p.H96R	SIDM01242	Melanoma	GDSC	FFPFVE	LIG_APCC_ABBA_1	0.25
p.H96R	ACH-002162	Skin Cancer	CCLE	FFPFVE	LIG_APCC_ABBA_1	0.25
p.H96R	MMAC-SF	skin	COSMIC	FFPFVE	LIG_APCC_ABBA_1	0.25
p.L86Q	SIDM00256	Neuroblastoma	GDSC	FFPFVE	LIG_APCC_ABBA_1	0.2778
p.L86Q	ACH-002281	Neuroblastoma	CCLE	FFPFVE	LIG_APCC_ABBA_1	0.2778
p.L86Q	NB14	autonomic_ganglia	COSMIC	FFPFVE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03591	Complement factor H-related protein 1	LIG_APCC_ABBA_1	88:93	FFPFVE	APC,CDC20,FZR1	0.6298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons