DegronMD

Uniprot ID: P13051

Source protein: Uracil-DNA glycosylase

Source gene: UNG

Class: DEG_MDM2_SWIB_1

Location: 94:102

E3 ligase: MDM2

DEGRON score: 0.9073

ASA_SCORE: 55.2111

COIL: 0.3474

CONS_SCORE: 0.5244

DSS_SCORE: 0.1868

HELIX: 0.6287

FCONS_SCORE: 1.188

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G95A	TCGA-22-5479	LUSC	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	0.6429
p.K99M	TCGA-AA-A010	COAD	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	0.6951
p.R88H	TCGA-SX-A7SM	KIRP	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	0.1667
p.R88H	DO49785	KIRP	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	0.1667
p.G86A	DO27287	LUSC	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	0.1111
p.G98E	DO229148	THCA	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13051	Uracil-DNA glycosylase	DEG_MDM2_SWIB_1	94:102	FGESWKKHL	MDM2	0.9073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons