DegronMD - P13051(UNG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G95A	TCGA-22-5479	LUSC	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation altering degron motif	0.6429
p.K49N	TCGA-50-6592	LUAD	TCGA	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation blocking ubiquitination signal	0.5278
p.K49N	DO23742	LUAD	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation blocking ubiquitination signal	0.5278
p.K99M	TCGA-AA-A010	COAD	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation altering degron motif	0.6951
p.P62H	TCGA-AO-A0JD	BRCA	TCGA	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.6583
p.P62H	DO2860	BRCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.6583
p.G59R	TCGA-CN-6016	HNSC	TCGA	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.6457
p.P52Q	TCGA-G2-A2EJ	BLCA	TCGA	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.1667
p.P52Q	DO554	BLCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.1667
p.R88H	TCGA-SX-A7SM	KIRP	TCGA	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation rewiring degron network	0.1667
p.R88H	DO49785	KIRP	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation rewiring degron network	0.1667
p.P65L	DO228761	GACA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.3056
p.G50R	DO14470	HNSC	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation blocking ubiquitination signal	0.5556
p.G86A	DO27287	LUSC	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation rewiring degron network	0.1111
p.G98E	DO229148	THCA	ICGC	FGESWKKHL	DEG_MDM2_SWIB_1	94:102	Mutation altering degron motif	0.7199
p.P52L	DO229234	THCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.1667
p.I74V	ACH-001063	Ovarian Cancer	CCLE	PGTPPSS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.0556

Kaplan plot for UNG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNG

UniProt ID: P13051

Entrez ID: 7374

Protein name: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNG in