DegronMD

Uniprot ID: P13051

Source protein: Uracil-DNA glycosylase

Source gene: UNG

Class: DEG_SCF_FBW7_1

Location: 58:64

E3 ligase: FBXW7

DEGRON score: 0.9635

ASA_SCORE: 76.6571

COIL: 0.9587

CONS_SCORE: 0.3489

DSS_SCORE: 0.7906

HELIX: 0.0144

FCONS_SCORE: 0.957

RIG_SCORE: 0.5315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K49N	TCGA-50-6592	LUAD	TCGA	PGTPPSS	DEG_SCF_FBW7_1	0.5278
p.K49N	DO23742	LUAD	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.5278
p.P62H	TCGA-AO-A0JD	BRCA	TCGA	PGTPPSS	DEG_SCF_FBW7_1	0.6583
p.P62H	DO2860	BRCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.6583
p.G59R	TCGA-CN-6016	HNSC	TCGA	PGTPPSS	DEG_SCF_FBW7_1	0.6457
p.P52Q	TCGA-G2-A2EJ	BLCA	TCGA	PGTPPSS	DEG_SCF_FBW7_1	0.1667
p.P52Q	DO554	BLCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.1667
p.P65L	DO228761	GACA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.3056
p.G50R	DO14470	HNSC	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.5556
p.P52L	DO229234	THCA	ICGC	PGTPPSS	DEG_SCF_FBW7_1	0.1667
p.I74V	ACH-001063	Ovarian Cancer	CCLE	PGTPPSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13051	Uracil-DNA glycosylase	DEG_SCF_FBW7_1	58:64	PGTPPSS	FBXW7	0.9635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons