DegronMD

Uniprot ID: Q96RG2

Source protein: PAS domain-containing serine/threonine-protein kinase

Source gene: PASK

Class: DEG_MDM2_SWIB_1

Location: 1010:1017

E3 ligase: MDM2

DEGRON score: 0.5663

ASA_SCORE: 24.3875

COIL: 0.138

CONS_SCORE: 0.6741

DSS_SCORE: 0.1565

HELIX: 0.0075

FCONS_SCORE: 1.1941

RIG_SCORE: 0.8737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1013M	TCGA-AB-2828	LAML	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	0.6097
p.V1013M	TCGA-AX-A1CE	UCEC	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	0.6097
p.V1013M	DO21571	LAML	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.6097
p.V1013M	DO42280	UCEC	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.6097
p.G1011S	TCGA-FI-A2D4	UCEC	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	0.5882
p.G1011S	DO46390	OV	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.5882
p.G1011S	DO43170	UCEC	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.5882
p.V1017A	DO233732	GACA	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.6936
p.D1018E	DO229019	LICA	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.3056
p.A1016T	DO52151	PAEN	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RG2	PAS domain-containing serine/threonine-protein kinase	DEG_MDM2_SWIB_1	1010:1017	FGFVWTAV	MDM2	0.5663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons