DegronMD - Q96RG2(PASK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G488V	TCGA-85-8350	LUSC	TCGA	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.G488V	DO45492	LUSC	ICGC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A941S	TCGA-86-8673	LUAD	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.2778
p.A941S	DO26260	LUAD	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.2778
p.L57I	TCGA-A4-A5XZ	KIRP	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6063
p.L57I	DO44499	KIRP	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6063
p.E645K	TCGA-A5-A0G1	UCEC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1389
p.E645K	DO42472	UCEC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1389
p.P646S	TCGA-A5-A0G2	UCEC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.P646S	DO41235	UCEC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.R622Q	TCGA-AA-A00N	COAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.2222
p.R622Q	DO9876	COAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.2222
p.V1013M	TCGA-AB-2828	LAML	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6097
p.V1013M	TCGA-AX-A1CE	UCEC	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6097
p.V1013M	DO21571	LAML	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6097
p.V1013M	DO42280	UCEC	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6097
p.S956F	TCGA-AR-A2LE	BRCA	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation blocking phosphorylation signal	0.6389
p.S956F	DO1932	BRCA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation blocking phosphorylation signal	0.6389
p.A959T	TCGA-BG-A18B	UCEC	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1111
p.A959T	DO41452	UCEC	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1111
p.L961P	TCGA-BS-A0UJ	UCEC	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0556
p.L961P	DO42745	UCEC	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0556
p.L636I	TCGA-CK-6746	COAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation altering degron motif	0.6063
p.L636I	DO7938	COAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation altering degron motif	0.6063
p.W617C	TCGA-CN-6010	HNSC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.0833
p.W617C	DO14766	HNSC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.0833
p.P646Q	TCGA-CZ-5470	KIRC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.P646Q	DO19158	KIRC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.S40L	TCGA-EE-A2MR	SKCM	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation blocking phosphorylation signal	0.5
p.S40L	DO37819	SKCM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation blocking phosphorylation signal	0.5
p.S956C	TCGA-EW-A1OY	BRCA	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation blocking phosphorylation signal	0.6389
p.S956C	DO2743	BRCA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation blocking phosphorylation signal	0.6389
p.G1011S	TCGA-FI-A2D4	UCEC	TCGA	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.5882
p.G1011S	DO46390	OV	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.5882
p.G1011S	DO43170	UCEC	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.5882
p.H934Y	TCGA-FS-A1ZF	SKCM	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0833
p.H934Y	DO38039	SKCM	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0833
p.T62I	TCGA-GU-A42R	BLCA	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2222
p.T62I	SIDM00963	Breast Carcinoma	GDSC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2222
p.T62I	SIDM01699	Chondrosarcoma	GDSC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2222
p.P628S	TCGA-J4-A83I	PRAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation altering degron motif	0.6752
p.P628S	DO48600	PRAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation altering degron motif	0.6752
p.S42F	TCGA-W3-AA1V	SKCM	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation blocking phosphorylation signal	0.5556
p.S42F	DO51276	SKCM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation blocking phosphorylation signal	0.5556
p.L648M	TCGA-X6-A7WA	SARC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.0556
p.L648M	DO220312	SARC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.0556
p.S49C	DO1071	BRCA	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.P506H	DO230311	COCA	ICGC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2222
p.S55C	DO233103	GACA	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.7541
p.V1017A	DO233732	GACA	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6936
p.R56K	DO11854	GBM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6126
p.Q510K	DO228952	LICA	ICGC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.Q510K	DO229041	LICA	ICGC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.D1018E	DO229019	LICA	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation rewiring degron network	0.3056
p.P646T	DO229022	LICA	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.H955N	DO229024	LICA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.2222
p.Q503E	DO52686	MALY	ICGC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.D938N	DO222653	MELA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1944
p.D938N	ACH-000884	Skin Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1944
p.D938N	ACH-002159	Skin Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1944
p.P646L	DO46556	OV	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.1111
p.A1016T	DO52151	PAEN	ICGC	FGFVWTAV	DEG_MDM2_SWIB_1	1010:1017	Mutation altering degron motif	0.6028
p.T512A	SIDM00263	Ewing's Sarcoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.T512A	SIDM00014	Colorectal Carcinoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.T512A	SIDM00179	Melanoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.R944H	SIDM01045	Endometrial Carcinoma	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.8244
p.R944H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.8244
p.R944H	ACH-000942	Leukemia	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.8244
p.R944H	ACH-000978	Endometrial/Uterine Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.8244
p.R944H	EN	endometrium	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.8244
p.R937C	SIDM01133	Other Solid Cancers	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.1667
p.H934Q	SIDM01187	Breast Carcinoma	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0833
p.H934Q	ACH-000568	Breast Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0833
p.H934Q	UACC-812	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.0833
p.P487S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.P487S	ACH-000878	Lung Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.P487S	HCC-15	lung	COSMIC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0556
p.P641H	SIDM00079	Ovarian Carcinoma	GDSC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.25
p.P641H	ACH-000811	Ovarian Cancer	CCLE	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.25
p.P641H	SK-OV-3	ovary	COSMIC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	626:638	Mutation rewiring degron network	0.25
p.D508G	SIDM00083	Glioblastoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.D508G	ACH-000273	Brain Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.D508G	SF539	central nervous system	COSMIC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.R942K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.3056
p.R942K	ACH-000942	Leukemia	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation rewiring degron network	0.3056
p.P506T	ACH-000509	Lymphoma	CCLE	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2222
p.S496G	ACH-000900	Lung Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.S496G	NCI-H23	lung	COSMIC	LPVHGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.T62K	ACH-001199	Colon/Colorectal Cancer	CCLE	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2222
p.L54F	ACH-001367	Neuroblastoma	CCLE	RRNGLSRLC	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6981
p.T943P	UACC-812	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	MV-4-11	haematopoietic and lymphoid tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	HCC-78	lung	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	DMS-114	lung	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	G-402	soft tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919
p.T943P	HCC1419	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	943:951	Mutation altering degron motif	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PASK

UniProt ID: Q96RG2

Entrez ID: 23178

Protein name: PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PASK in