DegronMD

Uniprot ID: Q96RG2

Source protein: PAS domain-containing serine/threonine-protein kinase

Source gene: PASK

Class: DEG_APCC_DBOX_1

Location: 943:951

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6227

ASA_SCORE: 90.2

COIL: 0.5598

CONS_SCORE: 0.384

DSS_SCORE: 0.2876

HELIX: 0.4059

FCONS_SCORE: 0.9726

RIG_SCORE: 0.7708

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A941S	TCGA-86-8673	LUAD	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.2778
p.A941S	DO26260	LUAD	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.2778
p.S956F	TCGA-AR-A2LE	BRCA	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.6389
p.S956F	DO1932	BRCA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.6389
p.A959T	TCGA-BG-A18B	UCEC	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.1111
p.A959T	DO41452	UCEC	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.1111
p.L961P	TCGA-BS-A0UJ	UCEC	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.0556
p.L961P	DO42745	UCEC	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.0556
p.S956C	TCGA-EW-A1OY	BRCA	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.6389
p.S956C	DO2743	BRCA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.6389
p.H934Y	TCGA-FS-A1ZF	SKCM	TCGA	TRLFLASLP	DEG_APCC_DBOX_1	0.0833
p.H934Y	DO38039	SKCM	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.0833
p.H955N	DO229024	LICA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.2222
p.D938N	DO222653	MELA	ICGC	TRLFLASLP	DEG_APCC_DBOX_1	0.1944
p.D938N	ACH-000884	Skin Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.1944
p.D938N	ACH-002159	Skin Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.1944
p.R944H	SIDM01045	Endometrial Carcinoma	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	0.8244
p.R944H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	0.8244
p.R944H	ACH-000942	Leukemia	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.8244
p.R944H	ACH-000978	Endometrial/Uterine Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.8244
p.R944H	EN	endometrium	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.8244
p.R937C	SIDM01133	Other Solid Cancers	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	0.1667
p.H934Q	SIDM01187	Breast Carcinoma	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	0.0833
p.H934Q	ACH-000568	Breast Cancer	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.0833
p.H934Q	UACC-812	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.0833
p.R942K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	TRLFLASLP	DEG_APCC_DBOX_1	0.3056
p.R942K	ACH-000942	Leukemia	CCLE	TRLFLASLP	DEG_APCC_DBOX_1	0.3056
p.T943P	UACC-812	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	MV-4-11	haematopoietic_and_lymphoid_tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	HCC-78	lung	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	DMS-114	lung	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	G-402	soft_tissue	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919
p.T943P	HCC1419	breast	COSMIC	TRLFLASLP	DEG_APCC_DBOX_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRLFLASLP

Degron related mutations and impact score

Drug responses associated with PASK mutations

All proteins holding degron of TRLFLASLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RG2	PAS domain-containing serine/threonine-protein kinase	DEG_APCC_DBOX_1	943:951	TRLFLASLP	APC,CDC20,FZR1	0.6227	More...