DegronMD

Uniprot ID: Q96RG2

Source protein: PAS domain-containing serine/threonine-protein kinase

Source gene: PASK

Class: DEG_APCC_DBOX_1

Location: 50:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9908

ASA_SCORE: 87.4778

COIL: 0.7282

CONS_SCORE: 0.2861

DSS_SCORE: 0.3664

HELIX: 0.2233

FCONS_SCORE: 0.9965

RIG_SCORE: 0.7051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L57I	TCGA-A4-A5XZ	KIRP	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	0.6063
p.L57I	DO44499	KIRP	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.6063
p.S40L	TCGA-EE-A2MR	SKCM	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	0.5
p.S40L	DO37819	SKCM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.5
p.T62I	TCGA-GU-A42R	BLCA	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	0.2222
p.T62I	SIDM00963	Breast Carcinoma	GDSC	RRNGLSRLC	DEG_APCC_DBOX_1	0.2222
p.T62I	SIDM01699	Chondrosarcoma	GDSC	RRNGLSRLC	DEG_APCC_DBOX_1	0.2222
p.S42F	TCGA-W3-AA1V	SKCM	TCGA	RRNGLSRLC	DEG_APCC_DBOX_1	0.5556
p.S42F	DO51276	SKCM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.5556
p.S49C	DO1071	BRCA	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.3056
p.S55C	DO233103	GACA	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.7541
p.R56K	DO11854	GBM	ICGC	RRNGLSRLC	DEG_APCC_DBOX_1	0.6126
p.T62K	ACH-001199	Colon/Colorectal Cancer	CCLE	RRNGLSRLC	DEG_APCC_DBOX_1	0.2222
p.L54F	ACH-001367	Neuroblastoma	CCLE	RRNGLSRLC	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RG2	PAS domain-containing serine/threonine-protein kinase	DEG_APCC_DBOX_1	50:58	RRNGLSRLC	APC,CDC20,FZR1	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons