DegronMD

Uniprot ID: Q96RG2

Source protein: PAS domain-containing serine/threonine-protein kinase

Source gene: PASK

Class: LIG_APCC_ABBA_1

Location: 497:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9191

ASA_SCORE: 77.95

COIL: 0.7992

CONS_SCORE: 0.2864

DSS_SCORE: 0.6549

HELIX: 0.0695

FCONS_SCORE: 0.9691

RIG_SCORE: 0.6706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G488V	TCGA-85-8350	LUSC	TCGA	LPVHGE	LIG_APCC_ABBA_1	0.0833
p.G488V	DO45492	LUSC	ICGC	LPVHGE	LIG_APCC_ABBA_1	0.0833
p.P506H	DO230311	COCA	ICGC	LPVHGE	LIG_APCC_ABBA_1	0.2222
p.Q510K	DO228952	LICA	ICGC	LPVHGE	LIG_APCC_ABBA_1	0.1111
p.Q510K	DO229041	LICA	ICGC	LPVHGE	LIG_APCC_ABBA_1	0.1111
p.Q503E	DO52686	MALY	ICGC	LPVHGE	LIG_APCC_ABBA_1	0.3056
p.T512A	SIDM00263	Ewing's Sarcoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.T512A	SIDM00014	Colorectal Carcinoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.T512A	SIDM00179	Melanoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.P487S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.P487S	ACH-000878	Lung Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.P487S	HCC-15	lung	COSMIC	LPVHGE	LIG_APCC_ABBA_1	0.0556
p.D508G	SIDM00083	Glioblastoma	GDSC	LPVHGE	LIG_APCC_ABBA_1	0.1667
p.D508G	ACH-000273	Brain Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	0.1667
p.D508G	SF539	central_nervous_system	COSMIC	LPVHGE	LIG_APCC_ABBA_1	0.1667
p.P506T	ACH-000509	Lymphoma	CCLE	LPVHGE	LIG_APCC_ABBA_1	0.2222
p.S496G	ACH-000900	Lung Cancer	CCLE	LPVHGE	LIG_APCC_ABBA_1	0.3056
p.S496G	NCI-H23	lung	COSMIC	LPVHGE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RG2	PAS domain-containing serine/threonine-protein kinase	LIG_APCC_ABBA_1	497:502	LPVHGE	APC,CDC20,FZR1	0.9191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons