DegronMD

Uniprot ID: Q96RG2

Source protein: PAS domain-containing serine/threonine-protein kinase

Source gene: PASK

Class: DEG_ODPH_VHL_1

Location: 626:638

E3 ligase: VHL

DEGRON score: 0.998

ASA_SCORE: 58.7462

COIL: 0.8164

CONS_SCORE: 0.352

DSS_SCORE: 0.4138

HELIX: 0.0998

FCONS_SCORE: 1.1227

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E645K	TCGA-A5-A0G1	UCEC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1389
p.E645K	DO42472	UCEC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1389
p.P646S	TCGA-A5-A0G2	UCEC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.P646S	DO41235	UCEC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.R622Q	TCGA-AA-A00N	COAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.2222
p.R622Q	DO9876	COAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.2222
p.L636I	TCGA-CK-6746	COAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.6063
p.L636I	DO7938	COAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.6063
p.W617C	TCGA-CN-6010	HNSC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.0833
p.W617C	DO14766	HNSC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.0833
p.P646Q	TCGA-CZ-5470	KIRC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.P646Q	DO19158	KIRC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.P628S	TCGA-J4-A83I	PRAD	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.6752
p.P628S	DO48600	PRAD	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.6752
p.L648M	TCGA-X6-A7WA	SARC	TCGA	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.0556
p.L648M	DO220312	SARC	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.0556
p.P646T	DO229022	LICA	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.P646L	DO46556	OV	ICGC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.1111
p.P641H	SIDM00079	Ovarian Carcinoma	GDSC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.25
p.P641H	ACH-000811	Ovarian Cancer	CCLE	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.25
p.P641H	SK-OV-3	ovary	COSMIC	LAPSPSGMAGLSF	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RG2	PAS domain-containing serine/threonine-protein kinase	DEG_ODPH_VHL_1	626:638	LAPSPSGMAGLSF	VHL	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons