DegronMD

Uniprot ID: Q8IXB1

Source protein: DnaJ homolog subfamily C member 10

Source gene: DNAJC10

Class: LIG_APCC_ABBA_1

Location: 122:127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9656

ASA_SCORE: 75.3833

COIL: 0.8297

CONS_SCORE: 0.6134

DSS_SCORE: 0.1292

HELIX: 0.0855

FCONS_SCORE: 1.1726

RIG_SCORE: 0.8668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D127Y	TCGA-19-5956	GBM	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.7325
p.D127Y	DO13863	GBM	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.7325
p.D126N	TCGA-38-4631	LUAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.5821
p.D126N	DO24970	LUAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.5821
p.R136K	TCGA-A5-A2K5	UCEC	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.0833
p.R136K	DO41379	UCEC	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.0833
p.R119H	TCGA-A6-2686	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119H	TCGA-AZ-6598	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119H	TCGA-G4-6626	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119H	DO10276	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119H	DO7828	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119H	DO9594	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.25
p.P129S	TCGA-FW-A3R5	SKCM	TCGA	FGIYDD	LIG_APCC_ABBA_1	0.2778
p.P129S	DO37406	SKCM	ICGC	FGIYDD	LIG_APCC_ABBA_1	0.2778
p.N116D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FGIYDD	LIG_APCC_ABBA_1	0.1667
p.N116D	ACH-002256	Leukemia	CCLE	FGIYDD	LIG_APCC_ABBA_1	0.1667
p.N116D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FGIYDD	LIG_APCC_ABBA_1	0.1667
p.R119C	SIDM00179	Melanoma	GDSC	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119C	ACH-002165	Skin Cancer	CCLE	FGIYDD	LIG_APCC_ABBA_1	0.25
p.R119C	MZ2-MEL	skin	COSMIC	FGIYDD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXB1	DnaJ homolog subfamily C member 10	LIG_APCC_ABBA_1	122:127	FGIYDD	APC,CDC20,FZR1	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons