DegronMD - Q8IXB1(DNAJC10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D127Y	TCGA-19-5956	GBM	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.7325
p.D127Y	DO13863	GBM	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.7325
p.D126N	TCGA-38-4631	LUAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.5821
p.D126N	DO24970	LUAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.5821
p.G31V	TCGA-64-5781	LUAD	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.G31V	DO229019	LICA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.G31V	DO23740	LUAD	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.R16S	TCGA-98-A53B	LUSC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7427
p.R16S	DO52023	LUSC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7427
p.R136K	TCGA-A5-A2K5	UCEC	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.0833
p.R136K	DO41379	UCEC	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.0833
p.R119H	TCGA-A6-2686	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	TCGA-AZ-6598	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	TCGA-G4-6626	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	DO10276	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	DO7828	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	DO9594	COAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.D9G	TCGA-AP-A0LM	UCEC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.D9G	DO43306	UCEC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.E50K	TCGA-DK-A3X1	BLCA	TCGA	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.E50K	DO447	BLCA	ICGC	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.K7I	TCGA-EE-A2ML	SKCM	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.2222
p.K7I	DO222429	MELA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.2222
p.K7I	DO37408	SKCM	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.2222
p.P68L	TCGA-EO-A22U	UCEC	TCGA	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.P68L	DO43755	UCEC	ICGC	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.D9Y	TCGA-EY-A1GD	UCEC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.D9Y	DO42129	UCEC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.P129S	TCGA-FW-A3R5	SKCM	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.P129S	DO37406	SKCM	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.D9E	TCGA-KK-A59V	PRAD	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.D9E	DO51346	PRAD	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1667
p.L14F	DO48366	BLCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.3056
p.D8H	DO1076	BRCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1389
p.N70S	DO227987	COCA	ICGC	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1944
p.I18V	DO233267	GACA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5965
p.A27S	DO229019	LICA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2222
p.N70K	DO33037	PACA	ICGC	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1944
p.L19I	DO229218	THCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM00039	Ovarian Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM01569	Hepatocellular Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM01451	Pancreatic Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.N116D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.1667
p.N116D	ACH-002256	Leukemia	CCLE	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.1667
p.N116D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.1667
p.G31D	SIDM00238	Ovarian Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.G31D	OVK-18	ovary	COSMIC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.R119C	SIDM00179	Melanoma	GDSC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119C	ACH-002165	Skin Cancer	CCLE	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119C	MZ2-MEL	skin	COSMIC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.T32I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.T32I	ACH-001737	Leukemia	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.T32I	ACH-002222	Leukemia	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.T32I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.L19F	SIDM01735	Biliary Tract Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6981
p.L19F	ACH-000808	Bile Duct Cancer	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6981
p.A59S	ACH-000194	Non-Cancerous	CCLE	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.3056
p.R52K	ACH-001838	Bile Duct Cancer	CCLE	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1111

Kaplan plot for DNAJC10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC10

UniProt ID: Q8IXB1

Entrez ID: 54431

Protein name: DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJC10 in