DegronMD - Q8IXB1(DNAJC10)

FUNCTION: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of pro... View more >>

GO - Biological processes (BP): intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reti... View more >>

GO - Molecular function (MF): ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; chaperone binding [GO:0051087]; disulfide oxidoreductase activity [GO:0015036]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as a... View more >>

GO - Cellular component (CC): endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
KRIILCFLI	DEG_APCC_DBOX_1	APC,CDC20,FZR1	DnaJ homolog subfamily C member 10	15:23	More..
LKLHPD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	DnaJ homolog subfamily C member 10	60:65	More..
FGIYDD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	DnaJ homolog subfamily C member 10	122:127	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R16S	TCGA-98-A53B	LUSC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7427
p.R16S	DO52023	LUSC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7427
p.D127Y	TCGA-19-5956	GBM	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.7325
p.D127Y	DO13863	GBM	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.7325
p.L19I	DO229218	THCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM00039	Ovarian Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM01569	Hepatocellular Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19I	SIDM01451	Pancreatic Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7174
p.L19F	SIDM01735	Biliary Tract Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6981
p.L19F	ACH-000808	Bile Duct Cancer	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6981
p.I18V	DO233267	GACA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5965
p.D126N	TCGA-38-4631	LUAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.5821
p.D126N	DO24970	LUAD	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation altering degron motif	0.5821
p.L14F	DO48366	BLCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.3056
p.A59S	ACH-000194	Non-Cancerous	CCLE	LKLHPD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.3056
p.P129S	TCGA-FW-A3R5	SKCM	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.P129S	DO37406	SKCM	ICGC	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.R119H	TCGA-A6-2686	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	TCGA-AZ-6598	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.R119H	TCGA-G4-6626	COAD	TCGA	FGIYDD	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25

Showing 1 to 20 of 58 entries

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No resistance data available for this Degron.

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC10

UniProt ID: Q8IXB1

Entrez ID: 54431

Protein name: DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for DNAJC10 in