DegronMD

Uniprot ID: Q8IXB1

Source protein: DnaJ homolog subfamily C member 10

Source gene: DNAJC10

Class: LIG_APCC_ABBA_1

Location: 60:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5189

ASA_SCORE: 78.9

COIL: 0.5097

CONS_SCORE: 0.5829

DSS_SCORE: 0.4985

HELIX: 0.479

FCONS_SCORE: 1.0974

RIG_SCORE: 0.7312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E50K	TCGA-DK-A3X1	BLCA	TCGA	LKLHPD	LIG_APCC_ABBA_1	0.0556
p.E50K	DO447	BLCA	ICGC	LKLHPD	LIG_APCC_ABBA_1	0.0556
p.P68L	TCGA-EO-A22U	UCEC	TCGA	LKLHPD	LIG_APCC_ABBA_1	0.25
p.P68L	DO43755	UCEC	ICGC	LKLHPD	LIG_APCC_ABBA_1	0.25
p.N70S	DO227987	COCA	ICGC	LKLHPD	LIG_APCC_ABBA_1	0.1944
p.N70K	DO33037	PACA	ICGC	LKLHPD	LIG_APCC_ABBA_1	0.1944
p.A59S	ACH-000194	Non-Cancerous	CCLE	LKLHPD	LIG_APCC_ABBA_1	0.3056
p.R52K	ACH-001838	Bile Duct Cancer	CCLE	LKLHPD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXB1	DnaJ homolog subfamily C member 10	LIG_APCC_ABBA_1	60:65	LKLHPD	APC,CDC20,FZR1	0.5189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons