DegronMD

Uniprot ID: Q8IXB1

Source protein: DnaJ homolog subfamily C member 10

Source gene: DNAJC10

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6708

ASA_SCORE: 67.9444

COIL: 0.0217

CONS_SCORE: 0.3486

DSS_SCORE: 0.0003

HELIX: 0.9761

FCONS_SCORE: 1.2309

RIG_SCORE: 1.1185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G31V	TCGA-64-5781	LUAD	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.1111
p.G31V	DO229019	LICA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1111
p.G31V	DO23740	LUAD	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1111
p.R16S	TCGA-98-A53B	LUSC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.7427
p.R16S	DO52023	LUSC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.7427
p.D9G	TCGA-AP-A0LM	UCEC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.D9G	DO43306	UCEC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.K7I	TCGA-EE-A2ML	SKCM	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.2222
p.K7I	DO222429	MELA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.2222
p.K7I	DO37408	SKCM	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.2222
p.D9Y	TCGA-EY-A1GD	UCEC	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.D9Y	DO42129	UCEC	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.D9E	TCGA-KK-A59V	PRAD	TCGA	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.D9E	DO51346	PRAD	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1667
p.L14F	DO48366	BLCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.3056
p.D8H	DO1076	BRCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.1389
p.I18V	DO233267	GACA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.5965
p.A27S	DO229019	LICA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.2222
p.L19I	DO229218	THCA	ICGC	KRIILCFLI	DEG_APCC_DBOX_1	0.7174
p.L19I	SIDM00039	Ovarian Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.7174
p.L19I	SIDM01569	Hepatocellular Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.7174
p.L19I	SIDM01451	Pancreatic Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.7174
p.G31D	SIDM00238	Ovarian Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.1111
p.G31D	OVK-18	ovary	COSMIC	KRIILCFLI	DEG_APCC_DBOX_1	0.1111
p.T32I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.0833
p.T32I	ACH-001737	Leukemia	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	0.0833
p.T32I	ACH-002222	Leukemia	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	0.0833
p.T32I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	KRIILCFLI	DEG_APCC_DBOX_1	0.0833
p.L19F	SIDM01735	Biliary Tract Carcinoma	GDSC	KRIILCFLI	DEG_APCC_DBOX_1	0.6981
p.L19F	ACH-000808	Bile Duct Cancer	CCLE	KRIILCFLI	DEG_APCC_DBOX_1	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRIILCFLI

Degron related mutations and impact score

Drug responses associated with DNAJC10 mutations

All proteins holding degron of KRIILCFLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXB1	DnaJ homolog subfamily C member 10	DEG_APCC_DBOX_1	15:23	KRIILCFLI	APC,CDC20,FZR1	0.6708	More...