DegronMD

Uniprot ID: Q9H251

Source protein: Cadherin-23

Source gene: CDH23

Class: DEG_MDM2_SWIB_1

Location: 1134:1142

E3 ligase: MDM2

DEGRON score: 0.6575

ASA_SCORE: 48.8556

COIL: 0.2459

CONS_SCORE: 0.3214

DSS_SCORE: 0.2155

HELIX: 0.0083

FCONS_SCORE: 0.7079

RIG_SCORE: 0.8661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1135N	DO2401	BRCA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.6932
p.R1141C	DO222762	COCA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.8301
p.R1141H	DO233109	GACA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.8244
p.Q1128H	DO229025	LICA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.1667
p.A1134T	DO42033	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.7139
p.T1132M	DO41572	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.2778
p.T1132M	ACH-001517	Endometrial/Uterine Cancer	CCLE	FGRVWYRIL	DEG_MDM2_SWIB_1	0.2778
p.L1129M	DO43907	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.1944
p.R1151Q	SIDM00663	Melanoma	GDSC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.0833
p.R1151Q	Hs939-T	skin	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.0833
p.G1144C	SIDM00420	Bladder Carcinoma	GDSC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.2778
p.E1124K	NUGC-3	stomach	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.0556
p.R1150Q	Hs939-T	skin	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H251	Cadherin-23	DEG_MDM2_SWIB_1	1134:1142	FGRVWYRIL	MDM2	0.6575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons