DegronMD - Q9H251(CDH23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D783E	TCGA-49-AARO	LUAD	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.D783E	DO218924	LUAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.V159M	TCGA-AC-A62X	BRCA	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.R780H	TCGA-AD-6889	COAD	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R780H	DO8463	COAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R780H	DO230335	COCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R780H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R142Q	TCGA-AG-A002	READ	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7329
p.D785N	TCGA-AP-A0LM	UCEC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.D785N	TCGA-MA-AA3Z	CESC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.D785N	DO219722	CESC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.D785N	DO43306	UCEC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.R138Q	TCGA-B5-A3FH	UCEC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2222
p.E145K	TCGA-B6-A0RQ	BRCA	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7022
p.E145K	DO5535	BRCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7022
p.E133K	TCGA-BR-7959	STAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.A156T	TCGA-CN-A6UY	HNSC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.L801I	TCGA-E6-A1LX	UCEC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.L801I	DO41020	UCEC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.D158N	TCGA-EE-A3J5	SKCM	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833
p.E134D	TCGA-EO-A22X	UCEC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1111
p.M790V	TCGA-GV-A40G	BLCA	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6097
p.M790V	DO584	BLCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6097
p.V150M	TCGA-HU-A4G8	STAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.V150M	TCGA-WW-A8ZI	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.L144F	TCGA-KK-A8I8	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6981
p.P140T	TCGA-L9-A8F4	LUAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140T	DO49876	LUAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.V132L	TCGA-QG-A5YW	COAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.V132L	DO219106	COAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.S135P	TCGA-VN-A88R	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.S135P	DO49863	PRAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1389
p.K795N	TCGA-W3-AA1V	SKCM	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6918
p.K795N	DO51276	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6918
p.E782K	DO44029	BLCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.D1135N	DO2401	BRCA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation altering degron motif	0.6932
p.N804S	DO6358	CLLE	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R792H	DO9106	COAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.8244
p.V139I	DO9562	COAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.25
p.V139I	SIDM01944	Esophageal Carcinoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.25
p.R1141C	DO222762	COCA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation altering degron motif	0.8301
p.P140L	DO229010	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140L	DO229013	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140L	DO229016	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140L	DO229005	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140L	DO234282	ESAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.P140L	DO229346	LAML	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.G148R	DO229010	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.G148R	DO229013	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.G148R	DO229016	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.G148R	DO229003	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.G148R	DO229005	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.G148R	DO230934	LUSC	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6457
p.R1141H	DO233109	GACA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation altering degron motif	0.8244
p.A793S	DO52033	HNSC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7588
p.A793T	DO22536	LGG	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7139
p.I155F	DO228828	LICA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1667
p.G799V	DO229019	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2222
p.Q1128H	DO229025	LICA	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.1667
p.R786L	DO229027	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2778
p.G797C	DO229037	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2778
p.R780L	DO229008	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.V791G	DO48483	LIHC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7532
p.E143Q	DO25280	LUAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.5633
p.G796W	DO26478	LUSC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.T154A	DO228371	MALY	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1944
p.T154A	ACH-000315	Lymphoma	CCLE	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1944
p.E151K	DO220857	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.2778
p.R142W	DO220854	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.8634
p.D157N	DO222498	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.1111
p.R803Q	DO33032	PACA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R803Q	DO48894	PBCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R803Q	NCI-SNU-1	stomach	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.R786W	DO232224	PBCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2778
p.R781L	DO47623	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.A793P	DO219481	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7503
p.A1134T	DO42033	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation altering degron motif	0.7139
p.T1132M	DO41572	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.2778
p.T1132M	ACH-001517	Endometrial/Uterine Cancer	CCLE	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.2778
p.L1129M	DO43907	UCEC	ICGC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.1944
p.R1151Q	SIDM00663	Melanoma	GDSC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.0833
p.R1151Q	Hs939-T	skin	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.0833
p.I141F	SIDM00498	Colorectal Carcinoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.I141F	ACH-000970	Colon/Colorectal Cancer	CCLE	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.I141F	SNU-C5	large intestine	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.3056
p.T149A	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7139
p.T149A	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.7139
p.G1144C	SIDM00420	Bladder Carcinoma	GDSC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.2778
p.T791A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7139
p.T791A	PF-382	haematopoietic and lymphoid tissue	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7139
p.T796A	ACH-000937	Leukemia	CCLE	VEMTPPDS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.P142L	ACH-001518	Endometrial/Uterine Cancer	CCLE	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation altering degron motif	0.6471
p.E1124K	NUGC-3	stomach	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.0556
p.R1150Q	Hs939-T	skin	COSMIC	FGRVWYRIL	DEG_MDM2_SWIB_1	1134:1142	Mutation rewiring degron network	0.1111
p.V132M	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0556
p.N158Y	TE-4	oesophagus	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	142:149	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH23

UniProt ID: Q9H251

Entrez ID: 64072

Protein name: Cadherin-23 (Otocadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH23 in