DegronMD

Uniprot ID: Q9H251

Source protein: Cadherin-23

Source gene: CDH23

Class: DEG_SCF_FBW7_1

Location: 788:795

E3 ligase: FBXW7

DEGRON score: 0.9608

ASA_SCORE: 60.05

COIL: 0.8538

CONS_SCORE: 0.4284

DSS_SCORE: 0.2968

HELIX: 0.0204

FCONS_SCORE: 0.9898

RIG_SCORE: 0.756

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D783E	TCGA-49-AARO	LUAD	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.1944
p.D783E	DO218924	LUAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1944
p.R780H	TCGA-AD-6889	COAD	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R780H	DO8463	COAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R780H	DO230335	COCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R780H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.D785N	TCGA-AP-A0LM	UCEC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.25
p.D785N	TCGA-MA-AA3Z	CESC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.25
p.D785N	DO219722	CESC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.25
p.D785N	DO43306	UCEC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.25
p.L801I	TCGA-E6-A1LX	UCEC	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.1667
p.L801I	DO41020	UCEC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1667
p.M790V	TCGA-GV-A40G	BLCA	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.6097
p.M790V	DO584	BLCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.6097
p.K795N	TCGA-W3-AA1V	SKCM	TCGA	VEMTPPDS	DEG_SCF_FBW7_1	0.6918
p.K795N	DO51276	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.6918
p.E782K	DO44029	BLCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1667
p.N804S	DO6358	CLLE	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.0833
p.R792H	DO9106	COAD	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.8244
p.A793S	DO52033	HNSC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.7588
p.A793T	DO22536	LGG	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.7139
p.G799V	DO229019	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.2222
p.R786L	DO229027	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.2778
p.G797C	DO229037	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.2778
p.R780L	DO229008	LICA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.V791G	DO48483	LIHC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.7532
p.G796W	DO26478	LUSC	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.3056
p.R803Q	DO33032	PACA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R803Q	DO48894	PBCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R803Q	NCI-SNU-1	stomach	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	0.1111
p.R786W	DO232224	PBCA	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.2778
p.R781L	DO47623	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.1389
p.A793P	DO219481	SKCM	ICGC	VEMTPPDS	DEG_SCF_FBW7_1	0.7503
p.T791A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VEMTPPDS	DEG_SCF_FBW7_1	0.7139
p.T791A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VEMTPPDS	DEG_SCF_FBW7_1	0.7139
p.T796A	ACH-000937	Leukemia	CCLE	VEMTPPDS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEMTPPDS

Degron related mutations and impact score

Drug responses associated with CDH23 mutations

All proteins holding degron of VEMTPPDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H251	Cadherin-23	DEG_SCF_FBW7_1	788:795	VEMTPPDS	FBXW7	0.9608	More...