DegronMD

Uniprot ID: Q9H251

Source protein: Cadherin-23

Source gene: CDH23

Class: DEG_SCF_FBW7_1

Location: 142:149

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 55.6

COIL: 0.8836

CONS_SCORE: 0.5259

DSS_SCORE: 0.3514

HELIX: 0.0086

FCONS_SCORE: 1.0705

RIG_SCORE: 0.7343

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V159M	TCGA-AC-A62X	BRCA	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.0556
p.R142Q	TCGA-AG-A002	READ	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.7329
p.R138Q	TCGA-B5-A3FH	UCEC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.2222
p.E145K	TCGA-B6-A0RQ	BRCA	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.7022
p.E145K	DO5535	BRCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.7022
p.E133K	TCGA-BR-7959	STAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.0833
p.A156T	TCGA-CN-A6UY	HNSC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.1389
p.D158N	TCGA-EE-A3J5	SKCM	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.0833
p.E134D	TCGA-EO-A22X	UCEC	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.1111
p.V150M	TCGA-HU-A4G8	STAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.3056
p.V150M	TCGA-WW-A8ZI	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.3056
p.L144F	TCGA-KK-A8I8	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.6981
p.P140T	TCGA-L9-A8F4	LUAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140T	DO49876	LUAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.V132L	TCGA-QG-A5YW	COAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.0556
p.V132L	DO219106	COAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.0556
p.S135P	TCGA-VN-A88R	PRAD	TCGA	PENTPVGT	DEG_SCF_FBW7_1	0.1389
p.S135P	DO49863	PRAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.1389
p.V139I	DO9562	COAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.25
p.V139I	SIDM01944	Esophageal Carcinoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	0.25
p.P140L	DO229010	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140L	DO229013	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140L	DO229016	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140L	DO229005	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140L	DO234282	ESAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.P140L	DO229346	LAML	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.G148R	DO229010	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.G148R	DO229013	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.G148R	DO229016	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.G148R	DO229003	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.G148R	DO229005	COCA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.G148R	DO230934	LUSC	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.6457
p.I155F	DO228828	LICA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.1667
p.E143Q	DO25280	LUAD	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.5633
p.T154A	DO228371	MALY	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.1944
p.T154A	ACH-000315	Lymphoma	CCLE	PENTPVGT	DEG_SCF_FBW7_1	0.1944
p.E151K	DO220857	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.2778
p.R142W	DO220854	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.8634
p.D157N	DO222498	MELA	ICGC	PENTPVGT	DEG_SCF_FBW7_1	0.1111
p.I141F	SIDM00498	Colorectal Carcinoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	0.3056
p.I141F	ACH-000970	Colon/Colorectal Cancer	CCLE	PENTPVGT	DEG_SCF_FBW7_1	0.3056
p.I141F	SNU-C5	large_intestine	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	0.3056
p.T149A	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PENTPVGT	DEG_SCF_FBW7_1	0.7139
p.T149A	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	0.7139
p.P142L	ACH-001518	Endometrial/Uterine Cancer	CCLE	PENTPVGT	DEG_SCF_FBW7_1	0.6471
p.V132M	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	0.0556
p.N158Y	TE-4	oesophagus	COSMIC	PENTPVGT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PENTPVGT

Degron related mutations and impact score

Drug responses associated with CDH23 mutations

All proteins holding degron of PENTPVGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H251	Cadherin-23	DEG_SCF_FBW7_1	142:149	PENTPVGT	FBXW7	0.9813	More...