DegronMD

Uniprot ID: Q86XA9

Source protein: HEAT repeat-containing protein 5A

Source gene: HEATR5A

Class: DEG_MDM2_SWIB_1

Location: 25:33

E3 ligase: MDM2

DEGRON score: 0.5502

ASA_SCORE: 38.5111

COIL: 0.0156

CONS_SCORE: 0.4363

DSS_SCORE: 0.0108

HELIX: 0.983

FCONS_SCORE: 1.2795

RIG_SCORE: 1.0064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F25I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	FIFEWLRYL	DEG_MDM2_SWIB_1	0.7415
p.F25I	ACH-000980	Lung Cancer	CCLE	FIFEWLRYL	DEG_MDM2_SWIB_1	0.7415
p.F25I	NCI-H1155	lung	COSMIC	FIFEWLRYL	DEG_MDM2_SWIB_1	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XA9	HEAT repeat-containing protein 5A	DEG_MDM2_SWIB_1	25:33	FIFEWLRYL	MDM2	0.5502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons