DegronMD

Uniprot ID: Q86Z23

Source protein: Complement C1q-like protein 4

Source gene: C1QL4

Class: LIG_APCC_ABBA_1

Location: 233:238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9661

ASA_SCORE: 56.05

COIL: 0.4902

CONS_SCORE: 0.6224

DSS_SCORE: 0.5655

HELIX: 0.0062

FCONS_SCORE: 0.9654

RIG_SCORE: 0.864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D238N	TCGA-13-2057	OV	TCGA	FIIYPD	LIG_APCC_ABBA_1	0.6932
p.D238N	DO31320	OV	ICGC	FIIYPD	LIG_APCC_ABBA_1	0.6932
p.K226N	TCGA-44-6778	LUAD	TCGA	FIIYPD	LIG_APCC_ABBA_1	0.5833
p.K226N	DO25603	LUAD	ICGC	FIIYPD	LIG_APCC_ABBA_1	0.5833
p.T224N	DO229006	LICA	ICGC	FIIYPD	LIG_APCC_ABBA_1	0.0833
p.S228I	DO229213	THCA	ICGC	FIIYPD	LIG_APCC_ABBA_1	0.1944
p.Y236C	SIDM01113	Other Sarcomas	GDSC	FIIYPD	LIG_APCC_ABBA_1	0.7087
p.Y236C	ACH-000939	Sarcoma	CCLE	FIIYPD	LIG_APCC_ABBA_1	0.7087
p.Y236C	SK-UT-1	soft_tissue	COSMIC	FIIYPD	LIG_APCC_ABBA_1	0.7087
p.Y236S	NCI-H1563	lung	COSMIC	FIIYPD	LIG_APCC_ABBA_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Z23	Complement C1q-like protein 4	LIG_APCC_ABBA_1	233:238	FIIYPD	APC,CDC20,FZR1	0.9661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons