DegronMD

Uniprot ID: Q9BXL5

Source protein: Hemogen

Source gene: HEMGN

Class: LIG_APCC_ABBA_1

Location: 216:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5934

ASA_SCORE: 117.6333

COIL: 0.7015

CONS_SCORE: 0.6101

DSS_SCORE: 0.4447

HELIX: 0.2412

FCONS_SCORE: 0.9866

RIG_SCORE: 0.8

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A229D	TCGA-06-5416	GBM	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.1111
p.A229D	DO10880	GBM	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.1111
p.A223S	TCGA-85-A50Z	LUSC	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.A223S	DO45462	LUSC	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.D213Y	TCGA-AA-3510	COAD	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.25
p.D213Y	DO7783	COAD	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.25
p.D221Y	TCGA-AP-A056	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.7325
p.D221Y	TCGA-IB-7651	PAAD	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.7325
p.D221Y	DO46657	PAAD	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.7325
p.D221Y	DO43971	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.7325
p.D213N	TCGA-AX-A2HD	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.25
p.D213N	DO42608	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.25
p.H214R	TCGA-B5-A3FA	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.H214R	DO52402	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.S209Y	DO222884	COCA	ICGC	FKMYQD	LIG_APCC_ABBA_1	0.1389
p.D221N	SIDM00683	Prostate Carcinoma	GDSC	FKMYQD	LIG_APCC_ABBA_1	0.6932
p.D221N	ACH-000977	lymph_node	CCLE	FKMYQD	LIG_APCC_ABBA_1	0.6932
p.D221N	LNCaP-Clone-FGC	prostate	COSMIC	FKMYQD	LIG_APCC_ABBA_1	0.6932
p.H214Y	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.H214Y	ACH-000744	Lung Cancer	CCLE	FKMYQD	LIG_APCC_ABBA_1	0.2778
p.H214Y	NCI-H1623	lung	COSMIC	FKMYQD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL5	Hemogen	LIG_APCC_ABBA_1	216:221	FKMYQD	APC,CDC20,FZR1	0.5934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons