DegronMD - Q9BXL5(HEMGN)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A229D	TCGA-06-5416	GBM	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.1111
p.A229D	DO10880	GBM	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.1111
p.P338T	TCGA-34-8455	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1944
p.P338T	DO50095	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1944
p.S339Y	TCGA-56-6546	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation blocking phosphorylation signal	0.6667
p.S339Y	DO26542	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation blocking phosphorylation signal	0.6667
p.A223S	TCGA-85-A50Z	LUSC	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.A223S	DO45462	LUSC	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.H340Y	TCGA-98-8021	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.25
p.H340Y	DO27468	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.25
p.D213Y	TCGA-AA-3510	COAD	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.25
p.D213Y	DO7783	COAD	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.25
p.A337T	TCGA-AJ-A3EL	UCEC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1667
p.A337T	TCGA-BS-A0UV	UCEC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1667
p.A337T	DO41542	UCEC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1667
p.A337T	DO42793	UCEC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.1667
p.D221Y	TCGA-AP-A056	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.7325
p.D221Y	TCGA-IB-7651	PAAD	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.7325
p.D221Y	DO46657	PAAD	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.7325
p.D221Y	DO43971	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.7325
p.D213N	TCGA-AX-A2HD	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.25
p.D213N	DO42608	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.25
p.H214R	TCGA-B5-A3FA	UCEC	TCGA	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.H214R	DO52402	UCEC	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.H348Q	TCGA-D9-A6EC	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.647
p.H348Q	DO50291	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.647
p.S349F	TCGA-EE-A2MR	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.7982
p.S349F	DO37819	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.7982
p.E350K	TCGA-Z2-A8RT	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.7022
p.E350K	DO51301	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.7022
p.S209Y	DO222884	COCA	ICGC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.1389
p.S349Y	SIDM00684	Glioblastoma	GDSC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.712
p.S349Y	ACH-000595	Brain Cancer	CCLE	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation altering degron motif	0.712
p.D221N	SIDM00683	Prostate Carcinoma	GDSC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.6932
p.D221N	ACH-000977	lymph node	CCLE	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.6932
p.D221N	LNCaP-Clone-FGC	prostate	COSMIC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation altering degron motif	0.6932
p.H214Y	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.H214Y	ACH-000744	Lung Cancer	CCLE	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.H214Y	NCI-H1623	lung	COSMIC	FKMYQD	LIG_APCC_ABBA_1	216:221	Mutation rewiring degron network	0.2778
p.V334G	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.0833
p.V334G	ACH-000951	Lung Cancer	CCLE	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.0833
p.V334G	NCI-H2342	lung	COSMIC	IQETPHSE	DEG_SCF_FBW7_2	343:350	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEMGN

UniProt ID: Q9BXL5

Entrez ID: 55363

Protein name: Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEMGN in