DegronMD

Uniprot ID: Q9BXL5

Source protein: Hemogen

Source gene: HEMGN

Class: DEG_SCF_FBW7_2

Location: 343:350

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 108.75

COIL: 0.9289

CONS_SCORE: 0.6871

DSS_SCORE: 0.6575

HELIX: 0.0396

FCONS_SCORE: 1.4828

RIG_SCORE: 0.6649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P338T	TCGA-34-8455	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.1944
p.P338T	DO50095	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.1944
p.S339Y	TCGA-56-6546	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.6667
p.S339Y	DO26542	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.6667
p.H340Y	TCGA-98-8021	LUSC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.25
p.H340Y	DO27468	LUSC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.25
p.A337T	TCGA-AJ-A3EL	UCEC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.1667
p.A337T	TCGA-BS-A0UV	UCEC	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.1667
p.A337T	DO41542	UCEC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.1667
p.A337T	DO42793	UCEC	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.1667
p.H348Q	TCGA-D9-A6EC	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.647
p.H348Q	DO50291	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.647
p.S349F	TCGA-EE-A2MR	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.7982
p.S349F	DO37819	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.7982
p.E350K	TCGA-Z2-A8RT	SKCM	TCGA	IQETPHSE	DEG_SCF_FBW7_2	0.7022
p.E350K	DO51301	SKCM	ICGC	IQETPHSE	DEG_SCF_FBW7_2	0.7022
p.S349Y	SIDM00684	Glioblastoma	GDSC	IQETPHSE	DEG_SCF_FBW7_2	0.712
p.S349Y	ACH-000595	Brain Cancer	CCLE	IQETPHSE	DEG_SCF_FBW7_2	0.712
p.V334G	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	IQETPHSE	DEG_SCF_FBW7_2	0.0833
p.V334G	ACH-000951	Lung Cancer	CCLE	IQETPHSE	DEG_SCF_FBW7_2	0.0833
p.V334G	NCI-H2342	lung	COSMIC	IQETPHSE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL5	Hemogen	DEG_SCF_FBW7_2	343:350	IQETPHSE	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons