DegronMD

Uniprot ID: P04843

Source protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Source gene: RPN1

Class: LIG_APCC_ABBA_1

Location: 214:219

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6715

ASA_SCORE: 42.2667

COIL: 0.1757

CONS_SCORE: 0.6009

DSS_SCORE: 0.2491

HELIX: 0.0153

FCONS_SCORE: 1.2531

RIG_SCORE: 0.837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S210N	TCGA-49-AAR0	LUAD	TCGA	FKVHYE	LIG_APCC_ABBA_1	0.2222
p.L225M	TCGA-AZ-6598	COAD	TCGA	FKVHYE	LIG_APCC_ABBA_1	0.1667
p.T213N	TCGA-EO-A3AY	UCEC	TCGA	FKVHYE	LIG_APCC_ABBA_1	0.3056
p.I211M	DO52611	BOCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.25
p.Y215C	DO225035	BRCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.7087
p.Y215C	DO227817	BRCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.7087
p.E204V	DO10582	COAD	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.0556
p.P214L	DO51296	SKCM	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.7582
p.Y226H	DO48032	STAD	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.1389
p.D212H	DO43162	UCEC	ICGC	FKVHYE	LIG_APCC_ABBA_1	0.2778
p.S222N	SIDM00216	Colorectal Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	0.6944
p.S222N	ACH-000989	Colon/Colorectal Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	0.6944
p.S222N	SNU-175	large_intestine	COSMIC	FKVHYE	LIG_APCC_ABBA_1	0.6944
p.P223T	SIDM00587	Biliary Tract Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	0.2222
p.P223T	ACH-000976	Bile Duct Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	0.2222
p.P223T	HuCCT1	biliary_tract	COSMIC	FKVHYE	LIG_APCC_ABBA_1	0.2222
p.R204G	SIDM00534	Colorectal Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	0.0556
p.R204G	ACH-000986	Colon/Colorectal Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	0.0556
p.R204G	HT-115	large_intestine	COSMIC	FKVHYE	LIG_APCC_ABBA_1	0.0556
p.P223L	ACH-001863	Bile Duct Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	0.2222
p.L229M	C-33-A	cervix	COSMIC	FKVHYE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	LIG_APCC_ABBA_1	214:219	FKVHYE	APC,CDC20,FZR1	0.6715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons