DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
FKVHYE
Uniprot ID:
P04843
Source protein:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Source gene:
RPN1
Class:
LIG_APCC_ABBA_1
Location:
214:219
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6715
ASA_SCORE:
42.2667
COIL:
0.1757
CONS_SCORE:
0.6009
DSS_SCORE:
0.2491
HELIX:
0.0153
FCONS_SCORE:
1.2531
RIG_SCORE:
0.837
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P214L
DO51296
SKCM
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.7582
p.Y215C
DO225035
BRCA
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.7087
p.Y215C
DO227817
BRCA
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.7087
p.S222N
SIDM00216
Colorectal Carcinoma
GDSC
FKVHYE
LIG_APCC_ABBA_1
0.6944
p.S222N
ACH-000989
Colon/Colorectal Cancer
CCLE
FKVHYE
LIG_APCC_ABBA_1
0.6944
p.S222N
SNU-175
large_intestine
COSMIC
FKVHYE
LIG_APCC_ABBA_1
0.6944
p.T213N
TCGA-EO-A3AY
UCEC
TCGA
FKVHYE
LIG_APCC_ABBA_1
0.3056
p.D212H
DO43162
UCEC
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.2778
p.I211M
DO52611
BOCA
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.25
p.S210N
TCGA-49-AAR0
LUAD
TCGA
FKVHYE
LIG_APCC_ABBA_1
0.2222
p.P223T
SIDM00587
Biliary Tract Carcinoma
GDSC
FKVHYE
LIG_APCC_ABBA_1
0.2222
p.P223T
ACH-000976
Bile Duct Cancer
CCLE
FKVHYE
LIG_APCC_ABBA_1
0.2222
p.P223T
HuCCT1
biliary_tract
COSMIC
FKVHYE
LIG_APCC_ABBA_1
0.2222
p.P223L
ACH-001863
Bile Duct Cancer
CCLE
FKVHYE
LIG_APCC_ABBA_1
0.2222
p.L225M
TCGA-AZ-6598
COAD
TCGA
FKVHYE
LIG_APCC_ABBA_1
0.1667
p.Y226H
DO48032
STAD
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.1389
p.E204V
DO10582
COAD
ICGC
FKVHYE
LIG_APCC_ABBA_1
0.0556
p.R204G
SIDM00534
Colorectal Carcinoma
GDSC
FKVHYE
LIG_APCC_ABBA_1
0.0556
p.R204G
ACH-000986
Colon/Colorectal Cancer
CCLE
FKVHYE
LIG_APCC_ABBA_1
0.0556
p.R204G
HT-115
large_intestine
COSMIC
FKVHYE
LIG_APCC_ABBA_1
0.0556
p.L229M
C-33-A
cervix
COSMIC
FKVHYE
LIG_APCC_ABBA_1
0.0556
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Drug responses associated with RPN1 mutations
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Cancer
Mutation (In Degron?)
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All proteins holding degron of FKVHYE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P04843
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
LIG_APCC_ABBA_1
214:219
FKVHYE
APC,CDC20,FZR1
0.6715
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